How well do standard stroke outcome measures reflect quality of life?: A retrospective analysis of clinical trial data

Myzoon Ali, Rachael Fulton, Terry Quinn, Marian Brady, Audrey Bowen

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background and Purpose: Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. Methods: We examined primary outcomes by National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI) and modified Rankin Scale (mRS), and QoL by Stroke Impact Scale (SIS) and European Quality of Life Scale (EQ-5D) from the Virtual International Stroke Trials Archive (VISTA). Using Spearman correlations and logistic regression, we described the relationships between QoL mRS, NIHSS, and BI at 3 months, stratified by respondent (patient or proxy). Using x2 analyses, we examined the mismatch between good primary outcome (mRS ≤1, NIHSS ≤5, or BI ≥95) but poor QoL, and poor primary outcome (mRS ≥3, NIHSS ≥20, or BI ≤60) but good QoL. Results: Patient-assessed QoL had a stronger association with mRS (EQ-5D weighted score n=2987, P
    Original languageEnglish
    Pages (from-to)3161-3165
    Number of pages4
    JournalStroke
    Volume44
    Issue number11
    DOIs
    Publication statusPublished - Nov 2013

    Keywords

    • Barthel Index
    • Modified Rankin Scale
    • Outcome
    • Quality of life
    • Stroke
    • Trial

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