Abstract
Background and Purpose: Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. Methods: We examined primary outcomes by National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI) and modified Rankin Scale (mRS), and QoL by Stroke Impact Scale (SIS) and European Quality of Life Scale (EQ-5D) from the Virtual International Stroke Trials Archive (VISTA). Using Spearman correlations and logistic regression, we described the relationships between QoL mRS, NIHSS, and BI at 3 months, stratified by respondent (patient or proxy). Using x2 analyses, we examined the mismatch between good primary outcome (mRS ≤1, NIHSS ≤5, or BI ≥95) but poor QoL, and poor primary outcome (mRS ≥3, NIHSS ≥20, or BI ≤60) but good QoL. Results: Patient-assessed QoL had a stronger association with mRS (EQ-5D weighted score n=2987, P
Original language | English |
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Pages (from-to) | 3161-3165 |
Number of pages | 4 |
Journal | Stroke |
Volume | 44 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2013 |
Keywords
- Barthel Index
- Modified Rankin Scale
- Outcome
- Quality of life
- Stroke
- Trial