Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9

A. Mobasheri; G. Neama; S. Bell; S. Richardson; S. D. Carter

doi:10.1006/cbir.2001.0850

Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9

A. Mobasheri, G. Neama, S. Bell, S. Richardson, S. D. Carter

Research output: Contribution to journal › Article › peer-review

Abstract

Glucose is an important metabolite and a structural precursor for articular cartilage and its transport has significant consequences for cartilage development and functional integrity. In this study the expression of facilitative glucose transporters (GLUTs) in human chondrocytes was investigated. Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes. Given the central role of glucose in chondrocyte physiology and metabolism, its regular provision via GLUTs will influence the metabolic activity and survival of chondrocytes in cartilage matrices. © 2002 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	297-300
Number of pages	3
Journal	Cell Biology International
Volume	26
Issue number	3
DOIs	https://doi.org/10.1006/cbir.2001.0850
Publication status	Published - 2002

Keywords

Articular cartilage
Chondrocyte
Facilitative glucose transporter
GLUT

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10.1006/cbir.2001.0850

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title = "Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9",

abstract = "Glucose is an important metabolite and a structural precursor for articular cartilage and its transport has significant consequences for cartilage development and functional integrity. In this study the expression of facilitative glucose transporters (GLUTs) in human chondrocytes was investigated. Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes. Given the central role of glucose in chondrocyte physiology and metabolism, its regular provision via GLUTs will influence the metabolic activity and survival of chondrocytes in cartilage matrices. {\textcopyright} 2002 Elsevier Science Ltd. All rights reserved.",

keywords = "Articular cartilage, Chondrocyte, Facilitative glucose transporter, GLUT",

author = "A. Mobasheri and G. Neama and S. Bell and S. Richardson and Carter, {S. D.}",

year = "2002",

doi = "10.1006/cbir.2001.0850",

language = "English",

volume = "26",

pages = "297--300",

journal = "Cell Biology International",

issn = "1065-6995",

publisher = "John Wiley & Sons Ltd",

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TY - JOUR

T1 - Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9

AU - Mobasheri, A.

AU - Neama, G.

AU - Bell, S.

AU - Richardson, S.

AU - Carter, S. D.

PY - 2002

Y1 - 2002

N2 - Glucose is an important metabolite and a structural precursor for articular cartilage and its transport has significant consequences for cartilage development and functional integrity. In this study the expression of facilitative glucose transporters (GLUTs) in human chondrocytes was investigated. Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes. Given the central role of glucose in chondrocyte physiology and metabolism, its regular provision via GLUTs will influence the metabolic activity and survival of chondrocytes in cartilage matrices. © 2002 Elsevier Science Ltd. All rights reserved.

AB - Glucose is an important metabolite and a structural precursor for articular cartilage and its transport has significant consequences for cartilage development and functional integrity. In this study the expression of facilitative glucose transporters (GLUTs) in human chondrocytes was investigated. Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes. Given the central role of glucose in chondrocyte physiology and metabolism, its regular provision via GLUTs will influence the metabolic activity and survival of chondrocytes in cartilage matrices. © 2002 Elsevier Science Ltd. All rights reserved.

KW - Articular cartilage

KW - Chondrocyte

KW - Facilitative glucose transporter

KW - GLUT

U2 - 10.1006/cbir.2001.0850

DO - 10.1006/cbir.2001.0850

M3 - Article

SN - 1065-6995

VL - 26

SP - 297

EP - 300

JO - Cell Biology International

JF - Cell Biology International

IS - 3

ER -

Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9

Abstract

Keywords

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