Human embryonic germ cells for future neuronal replacement therapy

Lee Turnpenny; Iain T. Cameron; Cosma M. Spalluto; Karen Piper Hanley; David I. Wilson; Neil A. Hanley

doi:10.1016/j.brainresbull.2005.08.014

Human embryonic germ cells for future neuronal replacement therapy

Lee Turnpenny, Iain T. Cameron, Cosma M. Spalluto, Karen Piper Hanley, David I. Wilson, Neil A. Hanley

Research output: Contribution to journal › Article › peer-review

Abstract

Stem cell therapy offers exciting potential for ambitious cellular replacement to treat human (h) disease, such as Parkinson's disease, Alzheimer's disease or even replacement of the cell death that follows thromboembolic stroke. The realisation of these treatments requires cellular resources possessing three essential characteristics: (i) self-renewal, (ii) the ability to differentiate to physiologically normal cell types and (iii) lack of tumourigenicity. Here, we describe work on human embryonic germ cells (hEGCs), a population of cells alongside human embryonic stem cells (hESCs) with the potential to address these issues. © 2005 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	76-82
Number of pages	6
Journal	Brain Research Bulletin
Volume	68
Issue number	1-2
DOIs	https://doi.org/10.1016/j.brainresbull.2005.08.014
Publication status	Published - 15 Dec 2005

Keywords

Embryo
Embryonic germ cell
Gonad
Human
Primordial germ cell
Stem cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.brainresbull.2005.08.014

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title = "Human embryonic germ cells for future neuronal replacement therapy",

abstract = "Stem cell therapy offers exciting potential for ambitious cellular replacement to treat human (h) disease, such as Parkinson's disease, Alzheimer's disease or even replacement of the cell death that follows thromboembolic stroke. The realisation of these treatments requires cellular resources possessing three essential characteristics: (i) self-renewal, (ii) the ability to differentiate to physiologically normal cell types and (iii) lack of tumourigenicity. Here, we describe work on human embryonic germ cells (hEGCs), a population of cells alongside human embryonic stem cells (hESCs) with the potential to address these issues. {\textcopyright} 2005 Elsevier Inc. All rights reserved.",

keywords = "Embryo, Embryonic germ cell, Gonad, Human, Primordial germ cell, Stem cell",

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AU - Turnpenny, Lee

AU - Cameron, Iain T.

AU - Spalluto, Cosma M.

AU - Hanley, Karen Piper

AU - Wilson, David I.

AU - Hanley, Neil A.

PY - 2005/12/15

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N2 - Stem cell therapy offers exciting potential for ambitious cellular replacement to treat human (h) disease, such as Parkinson's disease, Alzheimer's disease or even replacement of the cell death that follows thromboembolic stroke. The realisation of these treatments requires cellular resources possessing three essential characteristics: (i) self-renewal, (ii) the ability to differentiate to physiologically normal cell types and (iii) lack of tumourigenicity. Here, we describe work on human embryonic germ cells (hEGCs), a population of cells alongside human embryonic stem cells (hESCs) with the potential to address these issues. © 2005 Elsevier Inc. All rights reserved.

AB - Stem cell therapy offers exciting potential for ambitious cellular replacement to treat human (h) disease, such as Parkinson's disease, Alzheimer's disease or even replacement of the cell death that follows thromboembolic stroke. The realisation of these treatments requires cellular resources possessing three essential characteristics: (i) self-renewal, (ii) the ability to differentiate to physiologically normal cell types and (iii) lack of tumourigenicity. Here, we describe work on human embryonic germ cells (hEGCs), a population of cells alongside human embryonic stem cells (hESCs) with the potential to address these issues. © 2005 Elsevier Inc. All rights reserved.

KW - Embryo

KW - Embryonic germ cell

KW - Gonad

KW - Human

KW - Primordial germ cell

KW - Stem cell

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M3 - Article

SN - 0361-9230

VL - 68

SP - 76

EP - 82

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 1-2

ER -

Human embryonic germ cells for future neuronal replacement therapy

Abstract

Keywords

UN SDGs

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