Human pancreas development

Rachel Jennings; Andrew Berry; James Strutt; Dave T Gerrard; Neil Hanley

doi:10.1242/dev.120063

Human pancreas development

Rachel Jennings, Andrew Berry, James Strutt, Dave T Gerrard, Neil Hanley

Research output: Contribution to journal › Article › peer-review

Abstract

A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.

Original language	English
Pages (from-to)	3126-3137
Number of pages	11
Journal	Development (Cambridge)
Volume	142
DOIs	https://doi.org/10.1242/dev.120063
Publication status	Published - 2015

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10.1242/dev.120063Licence: CC BY

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title = "Human pancreas development",

abstract = "A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.",

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AU - Berry, Andrew

AU - Strutt, James

AU - Gerrard, Dave T

AU - Hanley, Neil

PY - 2015

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AB - A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.

U2 - 10.1242/dev.120063

DO - 10.1242/dev.120063

M3 - Article

SN - 0950-1991

VL - 142

SP - 3126

EP - 3137

JO - Development (Cambridge)

JF - Development (Cambridge)

ER -

Human pancreas development

Abstract

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