@article{e8b22c9a46b64f5e8962cf65c01740b9,
title = "Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria",
abstract = "The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.",
keywords = "Mitochondria, PNPase, Polynucleotide phosphorylase, RNA degradation",
author = "Jan Piwowarski and Pawel Grzechnik and Andrzej Dziembowski and Aleksandra Dmochowska and Michal Minczuk and Stepien, {Piotr P.}",
note = "Funding Information: We thank Professor Ewa Bartnik for critical reading of the manuscript. Professor J. Moraczewski is acknowledged for his help with confocal microscopy. This research has been supported by the Polish State Committee for Scientific Research, grants KBN 3 P04A 07822, and KBN 4P04A 01818, the EU Centre of Excellence for Molecular Biology, Poland, No. ICA1-CT-2000-70010, and the EU Centre of Excellence for Multi-scale Biomolecular Modelling, Bioinformatics and Applications, Poland. We also acknowledge the financial support of the European Commission (QLG1-CT-2001-00966).",
year = "2003",
month = jun,
day = "20",
doi = "10.1016/S0022-2836(03)00528-X",
language = "English",
volume = "329",
pages = "853--857",
journal = "Journal of molecular biology",
issn = "0022-2836",
publisher = "Academic Press",
number = "5",
}