Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria

Jan Piwowarski, Pawel Grzechnik, Andrzej Dziembowski, Aleksandra Dmochowska, Michal Minczuk, Piotr P. Stepien

Research output: Contribution to journalArticlepeer-review


The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

Original languageEnglish
Pages (from-to)853-857
Number of pages5
JournalJournal of molecular biology
Issue number5
Publication statusPublished - 20 Jun 2003


  • Mitochondria
  • PNPase
  • Polynucleotide phosphorylase
  • RNA degradation


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