Human regulatory B cells in health and disease: therapeutic potential

Claudia Mauri, Madhvi Menon

Research output: Contribution to journalReview articlepeer-review


Regulatory B cells (Bregs) modulate immune responses predominantly, although not exclusively, via the release of IL-10. The importance of human Bregs in the maintenance of immune homeostasis comes from a variety of immune-related pathologies, such as autoimmune diseases, cancers, and chronic infections that are often associated with abnormalities in Breg numbers or function. A continuous effort toward understanding Breg biology in healthy individuals will provide new opportunities to develop Breg immunotherapy that could prove beneficial in treating various immune-mediated pathologies. In this Review, we discuss findings regarding human Bregs, including their mechanisms of suppression and role in different disease settings. We also propose several therapeutic strategies targeting Bregs for better management of immune disorders.

Original languageEnglish
Pages (from-to)772-779
Number of pages8
JournalThe Journal of clinical investigation
Issue number3
Publication statusPublished - 1 Mar 2017


  • Animals
  • B-Lymphocytes, Regulatory/immunology
  • Humans
  • Immune System Diseases/immunology
  • Immunotherapy/methods
  • Interleukin-10/immunology


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