Human Skin: Composition, Structure and Visualisation Methods

Helen K. Graham, Alexander Eckersley, Matiss Ozols, Kieran T. Mellody, Michael J. Sherratt

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

In this chapter we discuss the molecular composition and structure of the epidermis, dermal-epidermal junction, dermis and hypodermis. We highlight the contribution of long-lived dermal collagens, elastic fibres, proteoglycans and hyaluronic acid to skin function and also consider the role of apparently “minor” skin components. In order to characterise both healthy skin, and the progression of disease and ageing, it is necessary to use microscopical approaches but in addition to conventional ex vivo techniques, which image in two dimensions, valuable information can be gained by complimentary non-invasive and 3D imaging technologies.
Original languageEnglish
Title of host publicationSkin Biophysics
Subtitle of host publicationFrom Experimental Characterisation to Advanced Modelling
EditorsGeorges Limbert
PublisherSpringer Nature
Chapter1
Pages1-18
Number of pages18
ISBN (Electronic)978-3-030-13279-8
ISBN (Print)978-3-030-13278-1
DOIs
Publication statusPublished - 2019

Publication series

NameStudies in Mechanobiology, Tissue Engineering and Biomaterials
Volume22

Keywords

  • Dermis
  • Epidermis
  • Micro-computed X-ray tomography (microCT)
  • Microscopy
  • Non-invasive imaging
  • Skin composition
  • Skin structure

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