Hyaluronan: Polysaccharide chaos to protein organisation

Anthony J. Day; John K. Sheehan

doi:10.1016/S0959-440X(00)00256-6

Hyaluronan: Polysaccharide chaos to protein organisation

Research output: Contribution to journal › Article › peer-review

Abstract

Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan-protein interactions. Various studies on hyaluronan-binding proteins suggest there is considerable diversity in their mode of interaction with hyaluronan, which might result in many different bound conformations of the polysaccharide.

Original language	English
Pages (from-to)	617-622
Number of pages	5
Journal	Current Opinion in Structural Biology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/S0959-440X(00)00256-6
Publication status	Published - 1 Sept 2001

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10.1016/S0959-440X(00)00256-6

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title = "Hyaluronan: Polysaccharide chaos to protein organisation",

abstract = "Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan-protein interactions. Various studies on hyaluronan-binding proteins suggest there is considerable diversity in their mode of interaction with hyaluronan, which might result in many different bound conformations of the polysaccharide.",

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AU - Sheehan, John K.

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AB - Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan-protein interactions. Various studies on hyaluronan-binding proteins suggest there is considerable diversity in their mode of interaction with hyaluronan, which might result in many different bound conformations of the polysaccharide.

UR - https://www.scopus.com/pages/publications/0035444147

U2 - 10.1016/S0959-440X(00)00256-6

DO - 10.1016/S0959-440X(00)00256-6

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VL - 11

SP - 617

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JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

IS - 5

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Hyaluronan: Polysaccharide chaos to protein organisation

Abstract

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