TY - JOUR
T1 - Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-α-2,3-Gal-β-O-PNP
AU - Harrison, J.A.
AU - Kartha, K.P.Ravindranathan
AU - Turnbull, W.Bruce
AU - Scheuerl, S.L.
AU - Naismith, J.H.
AU - Schenkman, S.
AU - Field, R.A.
PY - 2001
Y1 - 2001
N2 - NeuAc-alpha-2,3-Gal-beta-O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha-2,3-Gal-beta-O-PNP were apparent.
AB - NeuAc-alpha-2,3-Gal-beta-O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha-2,3-Gal-beta-O-PNP were apparent.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0035931354&partnerID=MN8TOARS
U2 - 10.1016/S0960-894X(00)00611-9
DO - 10.1016/S0960-894X(00)00611-9
M3 - Article
SN - 0960-894X
VL - 11
SP - 141
EP - 144
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 2
ER -