Hypothalamo-pituitary-adrenal axis in uraemia: Evidence for primary adrenal dysfunction?

A. C. Grant, R. S C Rodger, R. Mitchell, S. Gibson, A. White, W. R. Robertson

    Research output: Contribution to journalArticlepeer-review


    To study hypothalamo-pituitary-adrenal axis disturbances in chronic renal failure, we administered corticotrophin-releasing hormone to patients undergoing haemodialysis and CAPD and to normal controls. Cortisol, ACTH, and ACTH precursors were measured before and after corticotrophin-releasing hormone using sensitive and specific two-site assays. Baseline ACTH and cortisol were similar in all groups. Peak values occurred at 30 min (ACTH) and between 30 and 60 min (cortisol). The cortisol (but not the ACTH) responses were significantly reduced in patients with renal failure (P
    Original languageEnglish
    Pages (from-to)307-310
    Number of pages3
    JournalNephrology, Dialysis, Transplantation
    Issue number4
    Publication statusPublished - 1993


    • ACTH
    • Corticotrophin releasing hormone
    • Cortisol
    • Renal failure


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