Hypoxia in head and neck cancer

A. Y. Isa; T. H. Ward; C. M L West; N. J. Slevin; J. J. Homer

doi:10.1259/bjr/17904358

Hypoxia in head and neck cancer

A. Y. Isa, T. H. Ward, C. M L West, N. J. Slevin, J. J. Homer

Research output: Contribution to journal › Article › peer-review

Abstract

A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies. © 2006 The British Institute of Radiology.

Original language	English
Pages (from-to)	791-798
Number of pages	7
Journal	British Journal of Radiology
Volume	79
Issue number	946
DOIs	https://doi.org/10.1259/bjr/17904358
Publication status	Published - Oct 2006

Keywords

therapeutic use: Antibiotics, Antineoplastic
analysis: Basic Helix-Loop-Helix Transcription Factors
analysis: Biological Markers
Cell Hypoxia
Comet Assay
blood supply: Head and Neck Neoplasms
metabolism: Hemoglobins
Humans
analysis: Hypoxia-Inducible Factor 1, alpha Subunit
Microelectrodes
diagnostic use: Nitroimidazoles
administration & dosage: Oxygen
methods: Positron-Emission Tomography
Prognosis
therapeutic use: Radiation-Sensitizing Agents

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1259/bjr/17904358

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title = "Hypoxia in head and neck cancer",

abstract = "A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies. {\textcopyright} 2006 The British Institute of Radiology.",

keywords = "therapeutic use: Antibiotics, Antineoplastic, analysis: Basic Helix-Loop-Helix Transcription Factors, analysis: Biological Markers, Cell Hypoxia, Comet Assay, blood supply: Head and Neck Neoplasms, metabolism: Hemoglobins, Humans, analysis: Hypoxia-Inducible Factor 1, alpha Subunit, Microelectrodes, diagnostic use: Nitroimidazoles, administration & dosage: Oxygen, methods: Positron-Emission Tomography, Prognosis, therapeutic use: Radiation-Sensitizing Agents",

author = "Isa, {A. Y.} and Ward, {T. H.} and West, {C. M L} and Slevin, {N. J.} and Homer, {J. J.}",

year = "2006",

month = oct,

doi = "10.1259/bjr/17904358",

language = "English",

volume = "79",

pages = "791--798",

journal = "British Journal of Radiology",

issn = "1748-880X",

publisher = "British Institute of Radiology",

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TY - JOUR

T1 - Hypoxia in head and neck cancer

AU - Isa, A. Y.

AU - Ward, T. H.

AU - West, C. M L

AU - Slevin, N. J.

AU - Homer, J. J.

PY - 2006/10

Y1 - 2006/10

N2 - A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies. © 2006 The British Institute of Radiology.

AB - A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies. © 2006 The British Institute of Radiology.

KW - therapeutic use: Antibiotics, Antineoplastic

KW - analysis: Basic Helix-Loop-Helix Transcription Factors

KW - analysis: Biological Markers

KW - Cell Hypoxia

KW - Comet Assay

KW - blood supply: Head and Neck Neoplasms

KW - metabolism: Hemoglobins

KW - Humans

KW - analysis: Hypoxia-Inducible Factor 1, alpha Subunit

KW - Microelectrodes

KW - diagnostic use: Nitroimidazoles

KW - administration & dosage: Oxygen

KW - methods: Positron-Emission Tomography

KW - Prognosis

KW - therapeutic use: Radiation-Sensitizing Agents

U2 - 10.1259/bjr/17904358

DO - 10.1259/bjr/17904358

M3 - Article

SN - 1748-880X

VL - 79

SP - 791

EP - 798

JO - British Journal of Radiology

JF - British Journal of Radiology

IS - 946

ER -

Hypoxia in head and neck cancer

Abstract

Keywords

UN SDGs

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