Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas.

E Griffiths; S Pritchard; HR Valentine; N Whitchelo; P Bishop; M Ebert; PM Price; I Welch; CML. West

Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas.

E Griffiths, S Pritchard, HR Valentine, N Whitchelo, P Bishop, M Ebert, PM Price, I Welch, CML. West

Research output: Contribution to journal › Article › peer-review

Abstract

Hypoxia-inducible factor-1 (HIF-1)alpha expression was studied in the gastric carcinogenesis sequence and as a prognostic factor in surgically resected gastric and gastro-oesophageal junction tumours. Protein expression was examined using immunohistochemistry on formalin-fixed biopsies of normal mucosa (n=20), Helicobacter pylori associated gastritis (n=24), intestinal metaplasia (n=24), dysplasia (n=12) and intestinal (n=19) and diffuse (n=21) adenocarcinoma. The relationship between HIF-1alpha expression and prognosis was assessed in resection specimens from 177 patients with gastric and gastro-oesophageal junction adenocarcinoma. Hypoxia-inducible factor-1alpha expression was not observed in normal gastric mucosa but increased in density (P

Original language	English
Journal	Br J Cancer
Volume	96( 1)
Publication status	Published - 15 Jan 2007

Keywords

diagnosis: Adenocarcinoma
Aged
Aged, 80 and over
Biopsy
Disease Progression
diagnosis: Esophageal Neoplasms
Female
Follow-Up Studies
Humans
biosynthesis: Hypoxia-Inducible Factor 1, alpha Subunit
Immunohistochemistry
Male
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Predictive Value of Tests
Prognosis
Staining and Labeling
diagnosis: Stomach Neoplasms
Survival Rate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas.",

abstract = "Hypoxia-inducible factor-1 (HIF-1)alpha expression was studied in the gastric carcinogenesis sequence and as a prognostic factor in surgically resected gastric and gastro-oesophageal junction tumours. Protein expression was examined using immunohistochemistry on formalin-fixed biopsies of normal mucosa (n=20), Helicobacter pylori associated gastritis (n=24), intestinal metaplasia (n=24), dysplasia (n=12) and intestinal (n=19) and diffuse (n=21) adenocarcinoma. The relationship between HIF-1alpha expression and prognosis was assessed in resection specimens from 177 patients with gastric and gastro-oesophageal junction adenocarcinoma. Hypoxia-inducible factor-1alpha expression was not observed in normal gastric mucosa but increased in density (P",

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author = "E Griffiths and S Pritchard and HR Valentine and N Whitchelo and P Bishop and M Ebert and PM Price and I Welch and CML. West",

year = "2007",

month = jan,

day = "15",

language = "English",

volume = "96( 1)",

journal = "Br J Cancer",

issn = "1532-1827",

publisher = "Springer Nature",

}

TY - JOUR

T1 - Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas.

AU - Griffiths, E

AU - Pritchard, S

AU - Valentine, HR

AU - Whitchelo, N

AU - Bishop, P

AU - Ebert, M

AU - Price, PM

AU - Welch, I

AU - West, CML.

PY - 2007/1/15

Y1 - 2007/1/15

N2 - Hypoxia-inducible factor-1 (HIF-1)alpha expression was studied in the gastric carcinogenesis sequence and as a prognostic factor in surgically resected gastric and gastro-oesophageal junction tumours. Protein expression was examined using immunohistochemistry on formalin-fixed biopsies of normal mucosa (n=20), Helicobacter pylori associated gastritis (n=24), intestinal metaplasia (n=24), dysplasia (n=12) and intestinal (n=19) and diffuse (n=21) adenocarcinoma. The relationship between HIF-1alpha expression and prognosis was assessed in resection specimens from 177 patients with gastric and gastro-oesophageal junction adenocarcinoma. Hypoxia-inducible factor-1alpha expression was not observed in normal gastric mucosa but increased in density (P

AB - Hypoxia-inducible factor-1 (HIF-1)alpha expression was studied in the gastric carcinogenesis sequence and as a prognostic factor in surgically resected gastric and gastro-oesophageal junction tumours. Protein expression was examined using immunohistochemistry on formalin-fixed biopsies of normal mucosa (n=20), Helicobacter pylori associated gastritis (n=24), intestinal metaplasia (n=24), dysplasia (n=12) and intestinal (n=19) and diffuse (n=21) adenocarcinoma. The relationship between HIF-1alpha expression and prognosis was assessed in resection specimens from 177 patients with gastric and gastro-oesophageal junction adenocarcinoma. Hypoxia-inducible factor-1alpha expression was not observed in normal gastric mucosa but increased in density (P

KW - diagnosis: Adenocarcinoma

KW - Aged

KW - Aged, 80 and over

KW - Biopsy

KW - Disease Progression

KW - diagnosis: Esophageal Neoplasms

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - biosynthesis: Hypoxia-Inducible Factor 1, alpha Subunit

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasm Invasiveness

KW - Predictive Value of Tests

KW - Prognosis

KW - Staining and Labeling

KW - diagnosis: Stomach Neoplasms

KW - Survival Rate

M3 - Article

SN - 1532-1827

VL - 96( 1)

JO - Br J Cancer

JF - Br J Cancer

ER -

Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas.

Abstract

Keywords

UN SDGs

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