Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping

William Ollier, Amaury Vaysse, Abhirami Ratnakumar, Thomas Derrien, Erik Axelsson, Gerli Rosengren Pielberg, Snaevar Sigurdsson, Tove Fall, Eija H. Seppälä, Mark S T Hansen, Cindy T. Lawley, Elinor K. Karlsson, Danika Bannasch, Carles Vilà, Hannes Lohi, Francis Galibert, Merete Fredholm, Jens Häggström, Åke Hedhammar, Catherine AndréKerstin Lindblad-Toh, Christophe Hitte, Matthew T. Webster, Ake Hedhammar, Géraldine Battaille (Collaborator), Cécile Clercx (Collaborator), Tom Druet (Collaborator), Frédéric Farnir (Collaborator), Nathalie Faust (Collaborator), Michel Georges (Collaborator), Anne Sophie Lequarre (Collaborator), Anne Christine Merveille (Collaborator), Yukihide Momozawa (Collaborator), Marilou Ramos Pamplona (Collaborator), Dominique Peeters (Collaborator), Kerstin Ahlgren (Collaborator), Leif Andersson (Collaborator), Maja Arendt (Collaborator), Álvaro Martínez Barrio (Collaborator), Örjan Carlborg (Collaborator), Cecilia Johansson (Collaborator), Olle Kämpe (Collaborator), Jennifer Meadows (Collaborator), Katarina Tengvall (Collaborator), Göran Andersson (Collaborator), Susanne Björnerfeldt (Collaborator), Susanne Gustafsson (Collaborator), Jeanette Hansson (Collaborator), Katja Höglund (Collaborator), Marcin Kierczak (Collaborator), Ingrid Ljungvall (Collaborator), Malin Melin (Collaborator), Katarina Sundberg (Collaborator), Lorna Kennedy (Collaborator), Jonathan Massey (Collaborator), Simon Rothwell (Collaborator), Saija Ahonen (Collaborator), Marjo Hytönen (Collaborator), Kaisa Kyöstilä (Collaborator), Elisa Nevalainen (Collaborator), Majbritt Busk Madsen (Collaborator), Mette Sloth Mogensen (Collaborator), Celine Courtay-Cahen (Collaborator), Cathryn Mellersh (Collaborator), Mike Starkey (Collaborator), Stina Dahlgren (Collaborator), Frode Lingaas (Collaborator), Linn Mari Storengen (Collaborator), Caroline Wiik (Collaborator), Kim Boerkamp (Collaborator), Hille Fieten (Collaborator), Peter Leegwater (Collaborator), Gerard Rutteman (Collaborator), Frank Van Steenbeek (Collaborator), Tosso Leeb (Collaborator), Marta Owczarek-Lipska (Collaborator), Jesus Aguirre-Hernandez (Collaborator), David Sargan (Collaborator), Anne Thomas (Collaborator), Valérie Chetboul (Collaborator), Vassiliki Gouni (Collaborator), Laurent Tiret (Collaborator), Brian Catchpole (Collaborator), Anke Hendricks (Collaborator), Armand Sánchez Bonastre (Collaborator), Javier Quilez (Collaborator), Sean Callanan (Collaborator), Catherine Nolan (Collaborator), Joanna Dukes-McEwan (Collaborator), Hannah Copeland-Stephenson (Collaborator), Claude Favrot (Collaborator), Gerhard Wess (Collaborator), Johanna Wolf (Collaborator), Kate Millar (Collaborator), Anne Boland (Collaborator), Mark Lathrop (Collaborator), Diana Zelenika (Collaborator), Rupert J Quinnell (Collaborator), Ute Philipp (Collaborator)

    Research output: Contribution to journalArticlepeer-review


    The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits. Here we perform a comprehensive analysis using multiple test statistics to identify regions under selection in 509 dogs from 46 diverse breeds using a newly developed high-density genotyping array consisting of >170,000 evenly spaced SNPs. We first identify 44 genomic regions exhibiting extreme differentiation across multiple breeds. Genetic variation in these regions correlates with variation in several phenotypic traits that vary between breeds, and we identify novel associations with both morphological and behavioral traits. We next scan the genome for signatures of selective sweeps in single breeds, characterized by long regions of reduced heterozygosity and fixation of extended haplotypes. These scans identify hundreds of regions, including 22 blocks of homozygosity longer than one megabase in certain breeds. Candidate selection loci are strongly enriched for developmental genes. We chose one highly differentiated region, associated with body size and ear morphology, and characterized it using high-throughput sequencing to provide a list of variants that may directly affect these traits. This study provides a catalogue of genomic regions showing extreme reduction in genetic variation or population differentiation in dogs, including many linked to phenotypic variation. The many blocks of reduced haplotype diversity observed across the genome in dog breeds are the result of both selection and genetic drift, but extended blocks of homozygosity on a megabase scale appear to be best explained by selection. Further elucidation of the variants under selection will help to uncover the genetic basis of complex traits and disease. © 2011 Vaysse et al.
    Original languageEnglish
    Article numbere1002316
    JournalPL o S Genetics
    Issue number10
    Publication statusPublished - Oct 2011


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