Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

Alexander JP Fulton, Angela Lamarca, Christina Nuttall, Lynne McCallum, Rille Pihlak, Derek O'Reilly, Fiona Lalloo, Mairead Mcnamara, Richard Hubner, Tara Clancy, Juan Valle

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Abstract

BACKGROUND
Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family.

AIM
To assess the referral pathways for genetic consultations in PDAC.

METHODS
Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria.

RESULTS
Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population.

CONCLUSION
Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.
Original languageEnglish
Pages (from-to)102-116
Number of pages15
JournalWorld Journal of Gastrointestinal Oncology
Volume11
Issue number2
Early online date15 Feb 2019
DOIs
Publication statusPublished - 2019

Keywords

  • Genetic counselling
  • Pancreatic adenocarcinoma
  • Genetic consultation
  • BRCA
  • Germline

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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