Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

Alexander JP Fulton; Angela Lamarca; Christina Nuttall; Lynne McCallum; Rille Pihlak; Derek O'Reilly; Fiona Lalloo; Mairead Mcnamara; Richard Hubner; Tara Clancy; Juan Valle

doi:10.4251/wjgo.v11.i2.102

Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

Alexander JP Fulton
, Angela Lamarca
, Christina Nuttall
, Lynne McCallum
, Rille Pihlak
, Derek O'Reilly
, Fiona Lalloo
, Mairead Mcnamara
, Richard Hubner
, Tara Clancy
, Juan Valle

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND
Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family.

AIM
To assess the referral pathways for genetic consultations in PDAC.

METHODS
Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria.

RESULTS
Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population.

CONCLUSION
Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.

Original language	English
Pages (from-to)	102-116
Number of pages	15
Journal	World Journal of Gastrointestinal Oncology
Volume	11
Issue number	2
Early online date	15 Feb 2019
DOIs	https://doi.org/10.4251/wjgo.v11.i2.102
Publication status	Published - 2019

Keywords

Genetic counselling
Pancreatic adenocarcinoma
Genetic consultation
BRCA
Germline

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4251/wjgo.v11.i2.102

2019-01-10-Fulton et al 2019-FINAL ACCEPTED MANUSCRIPT WJGOAccepted author manuscript, 283 KB

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Fulton, A. JP., Lamarca, A., Nuttall, C., McCallum, L., Pihlak, R., O'Reilly, D., Lalloo, F., Mcnamara, M., Hubner, R., Clancy, T., & Valle, J. (2019). Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice. World Journal of Gastrointestinal Oncology, 11(2), 102-116. https://doi.org/10.4251/wjgo.v11.i2.102

@article{45d406397e324412b2657b426e683fb2,

title = "Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice",

abstract = "BACKGROUND Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. AIM To assess the referral pathways for genetic consultations in PDAC. METHODS Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria. RESULTS Four-hundred patients were eligible. Of 113 patients (28.3\%) meeting EUROPAC criteria, 8.8\% were referred for genetic opinion. Germ-line mutations were identified in 0.75\% of the whole population. CONCLUSION Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments. ",

keywords = "Genetic counselling, Pancreatic adenocarcinoma, Genetic consultation, BRCA, Germline",

author = "Fulton, \{Alexander JP\} and Angela Lamarca and Christina Nuttall and Lynne McCallum and Rille Pihlak and Derek O'Reilly and Fiona Lalloo and Mairead Mcnamara and Richard Hubner and Tara Clancy and Juan Valle",

year = "2019",

doi = "10.4251/wjgo.v11.i2.102",

language = "English",

volume = "11",

pages = "102--116",

journal = "World Journal of Gastrointestinal Oncology",

issn = "1948-5204",

publisher = "Baishideng Publishing Group Inc.",

number = "2",

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Fulton, AJP, Lamarca, A, Nuttall, C, McCallum, L, Pihlak, R, O'Reilly, D, Lalloo, F, Mcnamara, M, Hubner, R, Clancy, T & Valle, J 2019, 'Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice', World Journal of Gastrointestinal Oncology, vol. 11, no. 2, pp. 102-116. https://doi.org/10.4251/wjgo.v11.i2.102

TY - JOUR

T1 - Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

AU - Fulton, Alexander JP

AU - Lamarca, Angela

AU - Nuttall, Christina

AU - McCallum, Lynne

AU - Pihlak, Rille

AU - O'Reilly, Derek

AU - Lalloo, Fiona

AU - Mcnamara, Mairead

AU - Hubner, Richard

AU - Clancy, Tara

AU - Valle, Juan

PY - 2019

Y1 - 2019

N2 - BACKGROUND Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. AIM To assess the referral pathways for genetic consultations in PDAC. METHODS Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria. RESULTS Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population. CONCLUSION Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.

AB - BACKGROUND Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. AIM To assess the referral pathways for genetic consultations in PDAC. METHODS Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria. RESULTS Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population. CONCLUSION Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.

KW - Genetic counselling

KW - Pancreatic adenocarcinoma

KW - Genetic consultation

KW - BRCA

KW - Germline

UR - https://www.scopus.com/pages/publications/85061596874

U2 - 10.4251/wjgo.v11.i2.102

DO - 10.4251/wjgo.v11.i2.102

M3 - Article

SN - 1948-5204

VL - 11

SP - 102

EP - 116

JO - World Journal of Gastrointestinal Oncology

JF - World Journal of Gastrointestinal Oncology

IS - 2

ER -

Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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