Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

William McCoull; Matthew S. Addie; Alan M. Birch; Susan Birtles; Linda K. Buckett; Roger J. Butlin; Suzanne S. Bowker; Scott Boyd; Stephen Chapman; Robert D. M. Davies; Craig S. Donald; Clive P. Green; Chloe Jenner; Paul D. Kemmitt; Andrew G. Leach; Graeme C. Moody; Pablo Morentin Gutierrez; Nicholas J. Newcombe; Thorsten Nowak; Martin J. Packer; Alleyn T. Plowright; John Revill; Paul Schofield; Chris Sheldon; Steve Stokes; Andrew V. Turnbull; Steven J. Y. Wang; David P. Whalley; J. Matthew Wood

doi:10.1016/j.bmcl.2012.04.117

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

William McCoull, Matthew S. Addie, Alan M. Birch, Susan Birtles, Linda K. Buckett, Roger J. Butlin, Suzanne S. Bowker, Scott Boyd, Stephen Chapman, Robert D. M. Davies, Craig S. Donald, Clive P. Green, Chloe Jenner, Paul D. Kemmitt, Andrew G. Leach, Graeme C. Moody, Pablo Morentin Gutierrez, Nicholas J. Newcombe, Thorsten Nowak, Martin J. PackerAlleyn T. Plowright, John Revill, Paul Schofield, Chris Sheldon, Steve Stokes, Andrew V. Turnbull, Steven J. Y. Wang, David P. Whalley, J. Matthew Wood

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3873-3878
Journal	Bioorganic & medicinal chemistry letters
Volume	22
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2012.04.117
Publication status	Published - 15 Jun 2012

Keywords

DGAT
Oxadiazole
LLE
Obesity
PK/PD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bmcl.2012.04.117

Cite this

McCoull, W., Addie, M. S., Birch, A. M., Birtles, S., Buckett, L. K., Butlin, R. J., Bowker, S. S., Boyd, S., Chapman, S., Davies, R. D. M., Donald, C. S., Green, C. P., Jenner, C., Kemmitt, P. D., Leach, A. G., Moody, G. C., Gutierrez, P. M., Newcombe, N. J., Nowak, T., ... Wood, J. M. (2012). Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorganic & medicinal chemistry letters, 22(12), 3873-3878. https://doi.org/10.1016/j.bmcl.2012.04.117

@article{2a1aab994a7746b3b3d41c8ca4337723,

title = "Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes",

keywords = "DGAT, Oxadiazole, LLE, Obesity, PK/PD",

author = "William McCoull and Addie, {Matthew S.} and Birch, {Alan M.} and Susan Birtles and Buckett, {Linda K.} and Butlin, {Roger J.} and Bowker, {Suzanne S.} and Scott Boyd and Stephen Chapman and Davies, {Robert D. M.} and Donald, {Craig S.} and Green, {Clive P.} and Chloe Jenner and Kemmitt, {Paul D.} and Leach, {Andrew G.} and Moody, {Graeme C.} and Gutierrez, {Pablo Morentin} and Newcombe, {Nicholas J.} and Thorsten Nowak and Packer, {Martin J.} and Plowright, {Alleyn T.} and John Revill and Paul Schofield and Chris Sheldon and Steve Stokes and Turnbull, {Andrew V.} and Wang, {Steven J. Y.} and Whalley, {David P.} and Wood, {J. Matthew}",

year = "2012",

month = jun,

day = "15",

doi = "10.1016/j.bmcl.2012.04.117",

language = "English",

volume = "22",

pages = "3873--3878",

journal = "Bioorganic & medicinal chemistry letters",

issn = "0960-894X",

publisher = "Elsevier BV",

number = "12",

}

McCoull, W, Addie, MS, Birch, AM, Birtles, S, Buckett, LK, Butlin, RJ, Bowker, SS, Boyd, S, Chapman, S, Davies, RDM, Donald, CS, Green, CP, Jenner, C, Kemmitt, PD, Leach, AG, Moody, GC, Gutierrez, PM, Newcombe, NJ, Nowak, T, Packer, MJ, Plowright, AT, Revill, J, Schofield, P, Sheldon, C, Stokes, S, Turnbull, AV, Wang, SJY, Whalley, DP & Wood, JM 2012, 'Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes', Bioorganic & medicinal chemistry letters, vol. 22, no. 12, pp. 3873-3878. https://doi.org/10.1016/j.bmcl.2012.04.117

TY - JOUR

T1 - Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

AU - McCoull, William

AU - Addie, Matthew S.

AU - Birch, Alan M.

AU - Birtles, Susan

AU - Buckett, Linda K.

AU - Butlin, Roger J.

AU - Bowker, Suzanne S.

AU - Boyd, Scott

AU - Chapman, Stephen

AU - Davies, Robert D. M.

AU - Donald, Craig S.

AU - Green, Clive P.

AU - Jenner, Chloe

AU - Kemmitt, Paul D.

AU - Leach, Andrew G.

AU - Moody, Graeme C.

AU - Gutierrez, Pablo Morentin

AU - Newcombe, Nicholas J.

AU - Nowak, Thorsten

AU - Packer, Martin J.

AU - Plowright, Alleyn T.

AU - Revill, John

AU - Schofield, Paul

AU - Sheldon, Chris

AU - Stokes, Steve

AU - Turnbull, Andrew V.

AU - Wang, Steven J. Y.

AU - Whalley, David P.

AU - Wood, J. Matthew

PY - 2012/6/15

Y1 - 2012/6/15

KW - DGAT

KW - Oxadiazole

KW - LLE

KW - Obesity

KW - PK/PD

U2 - 10.1016/j.bmcl.2012.04.117

DO - 10.1016/j.bmcl.2012.04.117

M3 - Article

SN - 0960-894X

VL - 22

SP - 3873

EP - 3878

JO - Bioorganic & medicinal chemistry letters

JF - Bioorganic & medicinal chemistry letters

IS - 12

ER -