Identifying areas and risk groups with localised Mycobacterium tuberculosis transmission in northern England from 2010 to 2012: spatiotemporal analysis incorporating highly discriminatory genotyping data.

María Saavedra-Campos; William Welfare; Paul Cleary; Andrew Sails; Andy Burkitt; Daniel Hungerford; Ebere Okereke; Peter Acheson; Marko Petrovic

doi:10.1136/thoraxjnl-2014-206416

Identifying areas and risk groups with localised Mycobacterium tuberculosis transmission in northern England from 2010 to 2012: spatiotemporal analysis incorporating highly discriminatory genotyping data.

María Saavedra-Campos, William Welfare, Paul Cleary, Andrew Sails, Andy Burkitt, Daniel Hungerford, Ebere Okereke, Peter Acheson, Marko Petrovic

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Information on geographical variation in localised transmission of TB can inform targeting of disease control activities. The aim of this study was to estimate the proportion of TB attributable to localised transmission for the period 2010-2012 in northern England and to identify case characteristics associated with spatiotemporal-genotypical clusters. METHODS: We combined genotyping data with spatiotemporal scan statistics to define an indicator of localised TB transmission and identified factors associated with localised TB transmission thus defined in a multivariable logistics regression model. RESULTS: The estimated proportion of TB cases in northern England attributable to localised transmission was 10% (95% CI 9% to 12%). Clustered cases (cases which were spatiotemporally clustered with others of identical genotype) were on average younger than non-clustered cases (mean age 34 years vs 43 years; p value

Original language	English
Journal	Thorax
DOIs	https://doi.org/10.1136/thoraxjnl-2014-206416
Publication status	Published - 28 Apr 2015

Keywords

Clinical Epidemiology
Respiratory Infection
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/thoraxjnl-2014-206416

Fingerprint

Dive into the research topics of 'Identifying areas and risk groups with localised Mycobacterium tuberculosis transmission in northern England from 2010 to 2012: spatiotemporal analysis incorporating highly discriminatory genotyping data.'. Together they form a unique fingerprint.

Cite this

Saavedra-Campos, M., Welfare, W., Cleary, P., Sails, A., Burkitt, A., Hungerford, D., Okereke, E., Acheson, P., & Petrovic, M. (2015). Identifying areas and risk groups with localised Mycobacterium tuberculosis transmission in northern England from 2010 to 2012: spatiotemporal analysis incorporating highly discriminatory genotyping data. Thorax. https://doi.org/10.1136/thoraxjnl-2014-206416

@article{001ba36813964d8a9f2cee1203fad1a0,

title = "Identifying areas and risk groups with localised Mycobacterium tuberculosis transmission in northern England from 2010 to 2012: spatiotemporal analysis incorporating highly discriminatory genotyping data.",

abstract = "BACKGROUND: Information on geographical variation in localised transmission of TB can inform targeting of disease control activities. The aim of this study was to estimate the proportion of TB attributable to localised transmission for the period 2010-2012 in northern England and to identify case characteristics associated with spatiotemporal-genotypical clusters. METHODS: We combined genotyping data with spatiotemporal scan statistics to define an indicator of localised TB transmission and identified factors associated with localised TB transmission thus defined in a multivariable logistics regression model. RESULTS: The estimated proportion of TB cases in northern England attributable to localised transmission was 10% (95% CI 9% to 12%). Clustered cases (cases which were spatiotemporally clustered with others of identical genotype) were on average younger than non-clustered cases (mean age 34 years vs 43 years; p value",

keywords = "Clinical Epidemiology, Respiratory Infection, Tuberculosis",

author = "Mar{\'i}a Saavedra-Campos and William Welfare and Paul Cleary and Andrew Sails and Andy Burkitt and Daniel Hungerford and Ebere Okereke and Peter Acheson and Marko Petrovic",

year = "2015",

month = apr,

day = "28",

doi = "10.1136/thoraxjnl-2014-206416",

language = "English",

journal = "Thorax",

issn = "1468-3296",

publisher = "BMJ ",

}

Saavedra-Campos, M, Welfare, W, Cleary, P, Sails, A, Burkitt, A, Hungerford, D, Okereke, E, Acheson, P & Petrovic, M 2015, 'Identifying areas and risk groups with localised Mycobacterium tuberculosis transmission in northern England from 2010 to 2012: spatiotemporal analysis incorporating highly discriminatory genotyping data.', Thorax. https://doi.org/10.1136/thoraxjnl-2014-206416

TY - JOUR

T1 - Identifying areas and risk groups with localised Mycobacterium tuberculosis transmission in northern England from 2010 to 2012: spatiotemporal analysis incorporating highly discriminatory genotyping data.

AU - Saavedra-Campos, María

AU - Welfare, William

AU - Cleary, Paul

AU - Sails, Andrew

AU - Burkitt, Andy

AU - Hungerford, Daniel

AU - Okereke, Ebere

AU - Acheson, Peter

AU - Petrovic, Marko

PY - 2015/4/28

Y1 - 2015/4/28

N2 - BACKGROUND: Information on geographical variation in localised transmission of TB can inform targeting of disease control activities. The aim of this study was to estimate the proportion of TB attributable to localised transmission for the period 2010-2012 in northern England and to identify case characteristics associated with spatiotemporal-genotypical clusters. METHODS: We combined genotyping data with spatiotemporal scan statistics to define an indicator of localised TB transmission and identified factors associated with localised TB transmission thus defined in a multivariable logistics regression model. RESULTS: The estimated proportion of TB cases in northern England attributable to localised transmission was 10% (95% CI 9% to 12%). Clustered cases (cases which were spatiotemporally clustered with others of identical genotype) were on average younger than non-clustered cases (mean age 34 years vs 43 years; p value

AB - BACKGROUND: Information on geographical variation in localised transmission of TB can inform targeting of disease control activities. The aim of this study was to estimate the proportion of TB attributable to localised transmission for the period 2010-2012 in northern England and to identify case characteristics associated with spatiotemporal-genotypical clusters. METHODS: We combined genotyping data with spatiotemporal scan statistics to define an indicator of localised TB transmission and identified factors associated with localised TB transmission thus defined in a multivariable logistics regression model. RESULTS: The estimated proportion of TB cases in northern England attributable to localised transmission was 10% (95% CI 9% to 12%). Clustered cases (cases which were spatiotemporally clustered with others of identical genotype) were on average younger than non-clustered cases (mean age 34 years vs 43 years; p value

KW - Clinical Epidemiology

KW - Respiratory Infection

KW - Tuberculosis

U2 - 10.1136/thoraxjnl-2014-206416

DO - 10.1136/thoraxjnl-2014-206416

M3 - Article

C2 - 25920328

SN - 1468-3296

JO - Thorax

JF - Thorax

ER -