IgE expression in severe asthma with fungal sensitisation (SAFS) and ABPA

Livingstone Chishimba, David Denning, Caroline Moore, Gabriele Holtappels, Tineke Dutré, Claus Bachert

Research output: Contribution to conferencePoster


Livingstone Chishimba1,2,4, David Denning1,2,4, Caroline Moore4,5, GabrieleHoltappels3, Tineke Dutré3, Claus Bachert3.1Respiratory Medicine, University Hospital of South Manchester, Manchester,United Kingdom; 2Institute of Infl ammation and Repair, Respiratory  AllergyCentre, The University of Manchester, Manchester, United Kingdom; 3UpperAirways Research Laboratory (URL), University Hospital Ghent, De Pintelaan185, Belgium; 4National Aspergillosis Centre, University Hospital of SouthManchester, Manchester, United Kingdom; 5Regional Mycology ReferenceCentre, University Hospital of South Manchester, Manchester, United KingdomBACKGROUND: The role of IgE in patients with ABPA and SAFS is not fullyunderstood.OBJECTIVE: We sought to investigate whether total IgE (t-IgE), IgE toStaphylococcus aureus enterotoxins (SE- IgE) or IgE to Aspergillus fumigatus(Af-IgE) might be relevant to disease activity in adult asthmatic patients withABPA and SAFS.METHODS: SE- IgE, Af-IgE and -IgE concentrations were measured in adultcohorts with SAFS (n=39) and ABPA (n=42). Patients were retrospectivelyreviewed for clinical characteristics, lung function and radiological features.RESULTS: Mean t-IgE and Af -IgE levels were signifi cantly higher in ABPAthan in SAFS subjects (422.4 vs. 188.9, p=0.011; 9.3 vs. 2.3, p
Original languageEnglish
Publication statusPublished - 8 Sept 2013
EventEuropean respiratory society congress 2013 - Barcelona
Duration: 7 Sept 201311 Dec 2013


ConferenceEuropean respiratory society congress 2013


  • asthma, IgE, ABPA


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