IgE expression in severe asthma with fungal sensitisation (SAFS) and ABPA

Livingstone Chishimba; David Denning; Caroline Moore; Gabriele Holtappels; Tineke Dutré; Claus Bachert

IgE expression in severe asthma with fungal sensitisation (SAFS) and ABPA

Livingstone Chishimba, David Denning, Caroline Moore, Gabriele Holtappels, Tineke Dutré, Claus Bachert

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to conference › Poster

Abstract

Livingstone Chishimba1,2,4, David Denning1,2,4, Caroline Moore4,5, GabrieleHoltappels3, Tineke Dutré3, Claus Bachert3.1Respiratory Medicine, University Hospital of South Manchester, Manchester,United Kingdom; 2Institute of Infl ammation and Repair, Respiratory  AllergyCentre, The University of Manchester, Manchester, United Kingdom; 3UpperAirways Research Laboratory (URL), University Hospital Ghent, De Pintelaan185, Belgium; 4National Aspergillosis Centre, University Hospital of SouthManchester, Manchester, United Kingdom; 5Regional Mycology ReferenceCentre, University Hospital of South Manchester, Manchester, United KingdomBACKGROUND: The role of IgE in patients with ABPA and SAFS is not fullyunderstood.OBJECTIVE: We sought to investigate whether total IgE (t-IgE), IgE toStaphylococcus aureus enterotoxins (SE- IgE) or IgE to Aspergillus fumigatus(Af-IgE) might be relevant to disease activity in adult asthmatic patients withABPA and SAFS.METHODS: SE- IgE, Af-IgE and -IgE concentrations were measured in adultcohorts with SAFS (n=39) and ABPA (n=42). Patients were retrospectivelyreviewed for clinical characteristics, lung function and radiological features.RESULTS: Mean t-IgE and Af -IgE levels were signifi cantly higher in ABPAthan in SAFS subjects (422.4 vs. 188.9, p=0.011; 9.3 vs. 2.3, p

Original language	English
Publication status	Published - 8 Sept 2013
Event	European respiratory society congress 2013 - Barcelona Duration: 7 Sept 2013 → 11 Dec 2013

Conference

Conference	European respiratory society congress 2013
City	Barcelona
Period	7/09/13 → 11/12/13

Keywords

asthma, IgE, ABPA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@conference{d7753f01ffa245ea856bf05bd49b4e37,

title = "IgE expression in severe asthma with fungal sensitisation (SAFS) and ABPA",

abstract = "Livingstone Chishimba1,2,4, David Denning1,2,4, Caroline Moore4,5, GabrieleHoltappels3, Tineke Dutr{\'e}3, Claus Bachert3.1Respiratory Medicine, University Hospital of South Manchester, Manchester,United Kingdom; 2Institute of Infl ammation and Repair, Respiratory  AllergyCentre, The University of Manchester, Manchester, United Kingdom; 3UpperAirways Research Laboratory (URL), University Hospital Ghent, De Pintelaan185, Belgium; 4National Aspergillosis Centre, University Hospital of SouthManchester, Manchester, United Kingdom; 5Regional Mycology ReferenceCentre, University Hospital of South Manchester, Manchester, United KingdomBACKGROUND: The role of IgE in patients with ABPA and SAFS is not fullyunderstood.OBJECTIVE: We sought to investigate whether total IgE (t-IgE), IgE toStaphylococcus aureus enterotoxins (SE- IgE) or IgE to Aspergillus fumigatus(Af-IgE) might be relevant to disease activity in adult asthmatic patients withABPA and SAFS.METHODS: SE- IgE, Af-IgE and -IgE concentrations were measured in adultcohorts with SAFS (n=39) and ABPA (n=42). Patients were retrospectivelyreviewed for clinical characteristics, lung function and radiological features.RESULTS: Mean t-IgE and Af -IgE levels were signifi cantly higher in ABPAthan in SAFS subjects (422.4 vs. 188.9, p=0.011; 9.3 vs. 2.3, p",

keywords = "asthma, IgE, ABPA",

author = "Livingstone Chishimba and David Denning and Caroline Moore and Gabriele Holtappels and Tineke Dutr{\'e} and Claus Bachert",

year = "2013",

month = sep,

day = "8",

language = "English",

note = "European respiratory society congress 2013 ; Conference date: 07-09-2013 Through 11-12-2013",

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TY - CONF

T1 - IgE expression in severe asthma with fungal sensitisation (SAFS) and ABPA

AU - Chishimba, Livingstone

AU - Denning, David

AU - Moore, Caroline

AU - Holtappels, Gabriele

AU - Dutré, Tineke

AU - Bachert, Claus

PY - 2013/9/8

Y1 - 2013/9/8

N2 - Livingstone Chishimba1,2,4, David Denning1,2,4, Caroline Moore4,5, GabrieleHoltappels3, Tineke Dutré3, Claus Bachert3.1Respiratory Medicine, University Hospital of South Manchester, Manchester,United Kingdom; 2Institute of Infl ammation and Repair, Respiratory  AllergyCentre, The University of Manchester, Manchester, United Kingdom; 3UpperAirways Research Laboratory (URL), University Hospital Ghent, De Pintelaan185, Belgium; 4National Aspergillosis Centre, University Hospital of SouthManchester, Manchester, United Kingdom; 5Regional Mycology ReferenceCentre, University Hospital of South Manchester, Manchester, United KingdomBACKGROUND: The role of IgE in patients with ABPA and SAFS is not fullyunderstood.OBJECTIVE: We sought to investigate whether total IgE (t-IgE), IgE toStaphylococcus aureus enterotoxins (SE- IgE) or IgE to Aspergillus fumigatus(Af-IgE) might be relevant to disease activity in adult asthmatic patients withABPA and SAFS.METHODS: SE- IgE, Af-IgE and -IgE concentrations were measured in adultcohorts with SAFS (n=39) and ABPA (n=42). Patients were retrospectivelyreviewed for clinical characteristics, lung function and radiological features.RESULTS: Mean t-IgE and Af -IgE levels were signifi cantly higher in ABPAthan in SAFS subjects (422.4 vs. 188.9, p=0.011; 9.3 vs. 2.3, p

AB - Livingstone Chishimba1,2,4, David Denning1,2,4, Caroline Moore4,5, GabrieleHoltappels3, Tineke Dutré3, Claus Bachert3.1Respiratory Medicine, University Hospital of South Manchester, Manchester,United Kingdom; 2Institute of Infl ammation and Repair, Respiratory  AllergyCentre, The University of Manchester, Manchester, United Kingdom; 3UpperAirways Research Laboratory (URL), University Hospital Ghent, De Pintelaan185, Belgium; 4National Aspergillosis Centre, University Hospital of SouthManchester, Manchester, United Kingdom; 5Regional Mycology ReferenceCentre, University Hospital of South Manchester, Manchester, United KingdomBACKGROUND: The role of IgE in patients with ABPA and SAFS is not fullyunderstood.OBJECTIVE: We sought to investigate whether total IgE (t-IgE), IgE toStaphylococcus aureus enterotoxins (SE- IgE) or IgE to Aspergillus fumigatus(Af-IgE) might be relevant to disease activity in adult asthmatic patients withABPA and SAFS.METHODS: SE- IgE, Af-IgE and -IgE concentrations were measured in adultcohorts with SAFS (n=39) and ABPA (n=42). Patients were retrospectivelyreviewed for clinical characteristics, lung function and radiological features.RESULTS: Mean t-IgE and Af -IgE levels were signifi cantly higher in ABPAthan in SAFS subjects (422.4 vs. 188.9, p=0.011; 9.3 vs. 2.3, p

KW - asthma, IgE, ABPA

M3 - Poster

T2 - European respiratory society congress 2013

Y2 - 7 September 2013 through 11 December 2013

ER -

IgE expression in severe asthma with fungal sensitisation (SAFS) and ABPA

Abstract

Conference

Keywords

UN SDGs

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