IgE-mediated food allergy diagnosis: Current status and new perspectives

Riccardo Asero, Barbara K. Ballmer-Weber, Kirsten Beyer, Amedeo Conti, Ruta Dubakiene, Montserrat Fernandez-Rivas, Karin Hoffmann-Sommergruber, Jonas Lidholm, Tihomir Mustakov, Joanne N G Oude Elberink, Richard S H Pumphrey, Per Stahl Skov, Ronald Van Ree, Berber J. Vlieg-Boerstra, Reinhard Hitler, Jonathan O. Hourihane, Marek Kowalski, Nikos G. Papadopoulos, Jean Michel Wal, E. N Clare MillsStefan Vieths

    Research output: Contribution to journalArticlepeer-review


    In June 2005, the work of the EU Integrated Project EuroPrevall was started. EuroPrevall is the largest research project on food allergy ever performed in Europe. Major aims of the project are to generate for the first time reliable data on the prevalence of food allergies across Europe and on the natural course of food allergy development in infants. Improvement of in vitro diagnosis of food allergies is another important aim of the project. The present review summarizes current knowledge about the clinical presentation of food allergy and critically reviews available diagnostic tools at the beginning of the project period. A major problem in diagnosis is a relatively poor ,clinical specificity', i. e. both positive skin tests and in vitro tests for specific IgE are frequent in sensitized subjects without food allergy symptoms. So far, no in vitro test reliably predicts clinical food allergy. EuroPrevall aims at improving the predictive value of such tests by proceeding from diagnosis based on allergen extracts to purified allergen molecules, taking into account the affinity of the IgE-allergen interaction, and evaluating the potential of biological in vitro tests such as histamine release tests or basophil activation tests including assays performed with permanently growing cell lines. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)135-147
    Number of pages12
    JournalMolecular Nutrition and Food Research
    Issue number1
    Publication statusPublished - Jan 2007


    • Diagnosis
    • Food allergy
    • IgE
    • Skin tests


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