Image-based haemodynamics simulation in intracranial aneurysms

A. G. Radaelli, H. Bogunovíc, M. C. Villa Uriol, J. R. Cebral, A. F. Frangi*

*Corresponding author for this work

Research output: Chapter in Book/Conference proceedingChapterpeer-review

Abstract

Image-based haemodynamics simulation is a computational technique that combines patient-specific vascular modeling from medical images with Computational Fluid Dynamics techniques to approximate the complex blood flow characteristics of healthy and diseased vessels. Advances in image quality, algorithmic sophistication and computing power are enabling the introduction of such technology not only as a biomedical research tool but also for clinical practice. In particular, the interaction between haemodynamical forces and arterial wall biology is believed to play an important role in the formation, growth and, eventually, rupture of intracranial aneurysms. Due to the absence of ground truth image modalities to measure blood flow, image-based haemodynamics simulation represents an attractive tool to provide insight into the haemodynamics characteristics of intracranial aneurysms. In this chapter, we provide an overview of the main components of this technique, illustrate recent efforts in its validation and sensitivity analysis and discuss preliminary clinical studies and future research directions.

Original languageEnglish
Title of host publicationHandbook of Biomedical Imaging
Subtitle of host publicationMethodologies and Clinical Research
EditorsNikos Paragios, James Duncan, Nicholas Ayache
Place of PublicationNew York, NY
PublisherSpringer New York
Pages199-217
Number of pages19
ISBN (Electronic)9780387097497
ISBN (Print)9780387097480
DOIs
Publication statusPublished - 25 Mar 2015

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