Image guidance in radiation therapy for better cure of cancer

Vincent Grégoire, Matthias Guckenberger, Karin Haustermans, Jan J. W. Lagendijk, Cynthia Ménard, Richard Pötter, Ben J. Slotman, Kari Tanderup, Daniela Thorwarth, Marcel Van Herk, Daniel Zips

Research output: Contribution to journalArticlepeer-review


The key goal and main challenge of radiation therapy is the elimination of tumors without any concurring damages of the surrounding healthy tissues and organs. Radiation doses required to achieve sufficient cancer‐cell kill exceed in most clinical situations the dose that can be tolerated by the healthy tissues, especially when large parts of the affected organ are irradiated. High‐precision radiation oncology aims at optimizing tumor coverage, while sparing normal tissues. Medical imaging during the preparation phase, as well as in the treatment room for localization of the tumor and directing the beam, referred to as image‐guided radiotherapy (IGRT), is the cornerstone of precision radiation oncology. Sophisticated high‐resolution real‐time IGRT using X‐rays, computer tomography, magnetic resonance imaging, or ultrasound, enables delivery of high radiation doses to tumors without significant damage of healthy organs. IGRT is the most convincing success story of radiation oncology over the last decades, and it remains a major driving force of innovation, contributing to the development of personalized oncology, for example, through the use of real‐time imaging biomarkers for individualized dose delivery.
Original languageEnglish
Pages (from-to)1470-1491
JournalMolecular Oncology
Issue number7
Early online date13 Jun 2020
Publication statusPublished - 2 Jul 2020

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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