Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness

C. Eggers, B. Szelies, B. Bauer, K. Wienhard, H. Schröder, K. Herholz, W. D. Heiss

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Positron emission tomography with 11C-N-methyl-4-piperidyl-acetate (MP4A) was applied in eight healthy volunteers and two patients with mild Alzheimer's disease (AD) to assess acetylcholine esterase (AChE) activity in magnetic resonance imaging-identified brainstem nuclei. Uptake ratios in lateral dorsal tegmental and pedunculopontine nuclei relative to cerebellum yielded reproducible values for the AChE activity in controls and reduced values in AD, more marked in a patient with complaints of disturbed sleep. Cortical AChE activity was related to the extent of cognitive impairment which was more severe in the AD patient without sleep disturbance. This preliminary observational study demonstrates the feasibility to image and assess AChE activity in small nuclei of the brain stem. This approach may be helpful to investigate the interaction of various nuclei in the complex network regulating sleep and wakefulness in representative patient groups with documented sleep disturbance. © 2007 EFNS.
    Original languageEnglish
    Pages (from-to)690-693
    Number of pages3
    JournalEuropean Journal of Neurology
    Volume14
    Issue number6
    DOIs
    Publication statusPublished - Jun 2007

    Keywords

    • 11C-N-methyl-4-piperidyl-acetate
    • Acetylcholine esterase activity
    • Alzheimer's disease
    • Brainstem nuclei
    • Positron emission tomography
    • Sleep disturbance

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