Imaging of Ra-223 with a small-pixel CdTe detector

J W Scuffham, S Pani, P Seller, P J Sellin, M C Veale, M D Wilson, R J Cernik

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Ra-223 Dichloride (Xofigo (TM)) is a promising new radiopharmaceutical offering survival benefit and palliation of painful bone metastases in patients with hormone-refractory prostate cancer [1]. The response to radionuclide therapy and toxicity are directly linked to the absorbed radiation doses to the tumour and organs at risk respectively. Accurate dosimetry necessitates quantitative imaging of the biodistribution and kinetics of the radiopharmaceutical. Although primarily an alpha-emitter, Ra-223 also has some low-abundance X-ray and gamma emissions, which enable imaging of the biodistribution in the patient. However, the low spectral resolution of conventional gamma camera detectors makes in-vivo imaging of Ra-223 challenging. In this work, we present spectra and image data of anthropomorphic phantoms containing Ra-223 acquired with a small-pixel CdTe detector (HEXITEC) [2] with a pinhole collimator. Comparison is made with similar data acquired using a clinical gamma camera. The results demonstrate the advantages of the solid state detector in terms of scatter rejection and quantitative accuracy of the images. However, optimised collimation is needed in order for the sensitivity to rival current clinical systems. As different dosage levels and administration regimens for this drug are explored in current clinical trials, there is a clear need to develop improved imaging technologies that will enable personalised treatments to be designed for patients.
    Original languageEnglish
    JournalJournal of Instrumentation
    Volume10
    DOIs
    Publication statusPublished - 2015

    Keywords

    • pixelated detectors and associated vlsi electronics
    • scintigraphy and whole-body imaging
    • gamma camera
    • spect
    • pet pet/ct
    • coronary ct angiography (cta)
    • prostate-cancer
    • radionuclide therapy
    • bone metastases
    • survival

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