Imaging of the glioma microenvironment by TSPO PET

Bastian Zinnhardt, Federico Roncaroli, Claudia Foray, Erjon Agushi, Bahiya Osrah, Gaëlle Hugon, Andreas H Jacobs, Alexandra Winkeler

Research output: Contribution to journalReview articlepeer-review

Abstract

Gliomas are highly dynamic and heterogeneous tumours of the central nervous system (CNS). They constitute the most common neoplasm of the CNS and the second most common cause of death from intracranial disease after stroke. The advances in detailing the genetic profile of paediatric and adult gliomas along with the progress in MRI and PET multimodal molecular imaging technologies have greatly improved prognostic stratification of patients with glioma and informed on treatment decisions. Amino acid PET has already gained broad clinical application in the study of gliomas. PET imaging targeting the translocator protein (TSPO) has recently been applied to decipher the heterogeneity and dynamics of the tumour microenvironment (TME) and its various cellular components especially in view of targeted immune therapies with the goal to delineate pro- and anti-glioma immune cell modulation. The current review provides a comprehensive overview on the historical developments of TSPO PET for gliomas and summarizes the most relevant experimental and clinical data with regard to the assessment and quantification of various cellular components with the TME of gliomas by in vivo TSPO PET imaging.

Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Early online date15 Mar 2021
DOIs
Publication statusE-pub ahead of print - 15 Mar 2021

Keywords

  • Glioma
  • Glioma-associated microglia and macrophages
  • PET
  • TSPO
  • Tumour microenvironment

Fingerprint

Dive into the research topics of 'Imaging of the glioma microenvironment by TSPO PET'. Together they form a unique fingerprint.

Cite this