TY - JOUR
T1 - Imine reductases (IREDs)
AU - Mangas-Sanchez, Juan
AU - France, Scott P.
AU - Montgomery, Sarah L.
AU - Aleku, Godwin A.
AU - Man, Henry
AU - Sharma, Mahima
AU - Ramsden, Jeremy I.
AU - Grogan, Gideon
AU - Turner, Nicholas J.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.
AB - Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.
UR - http://www.scopus.com/inward/record.url?scp=85007107119&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2016.11.022
DO - 10.1016/j.cbpa.2016.11.022
M3 - Review article
C2 - 28038349
AN - SCOPUS:85007107119
SN - 1367-5931
VL - 37
SP - 19
EP - 25
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
ER -