Immune homeostasis in the respiratory tract and its impact on heterologous infection

Erika Wissinger; John Goulding; Tracy Hussell

doi:10.1016/j.smim.2009.01.005

Immune homeostasis in the respiratory tract and its impact on heterologous infection

Erika Wissinger
, John Goulding
, Tracy Hussell

Research output: Contribution to journal › Article › peer-review

Abstract

Innate immunity at mucosal surfaces requires additional restraint to prevent inflammation to innocuous antigens or commensal microorganisms. The threshold above which airway macrophages become activated is raised by site-specific factors including the receptors for transforming growth factor beta, interleukin 10 and CD200; the ligands for which are produced by, or expressed on, respiratory epithelium. We discuss such site-specific regulation and how this is continually altered by prior infections. Resetting of innate reactivity represents a strategy for limiting excessive inflammation, but in some may pre-dispose to secondary bacterial pneumonia. © 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	147-155
Number of pages	8
Journal	Seminars in Immunology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2009.01.005
Publication status	Published - Jun 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Homeostasis
Infection history
Innate immunity
Lung
Secondary bacterial pneumonia

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10.1016/j.smim.2009.01.005

Cite this

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title = "Immune homeostasis in the respiratory tract and its impact on heterologous infection",

abstract = "Innate immunity at mucosal surfaces requires additional restraint to prevent inflammation to innocuous antigens or commensal microorganisms. The threshold above which airway macrophages become activated is raised by site-specific factors including the receptors for transforming growth factor beta, interleukin 10 and CD200; the ligands for which are produced by, or expressed on, respiratory epithelium. We discuss such site-specific regulation and how this is continually altered by prior infections. Resetting of innate reactivity represents a strategy for limiting excessive inflammation, but in some may pre-dispose to secondary bacterial pneumonia. {\textcopyright} 2009 Elsevier Ltd. All rights reserved.",

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author = "Erika Wissinger and John Goulding and Tracy Hussell",

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AU - Wissinger, Erika

AU - Goulding, John

AU - Hussell, Tracy

N1 - AI070232-10, NIAID NIH HHS, United StatesG0400795, Medical Research Council, United Kingdom

PY - 2009/6

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N2 - Innate immunity at mucosal surfaces requires additional restraint to prevent inflammation to innocuous antigens or commensal microorganisms. The threshold above which airway macrophages become activated is raised by site-specific factors including the receptors for transforming growth factor beta, interleukin 10 and CD200; the ligands for which are produced by, or expressed on, respiratory epithelium. We discuss such site-specific regulation and how this is continually altered by prior infections. Resetting of innate reactivity represents a strategy for limiting excessive inflammation, but in some may pre-dispose to secondary bacterial pneumonia. © 2009 Elsevier Ltd. All rights reserved.

AB - Innate immunity at mucosal surfaces requires additional restraint to prevent inflammation to innocuous antigens or commensal microorganisms. The threshold above which airway macrophages become activated is raised by site-specific factors including the receptors for transforming growth factor beta, interleukin 10 and CD200; the ligands for which are produced by, or expressed on, respiratory epithelium. We discuss such site-specific regulation and how this is continually altered by prior infections. Resetting of innate reactivity represents a strategy for limiting excessive inflammation, but in some may pre-dispose to secondary bacterial pneumonia. © 2009 Elsevier Ltd. All rights reserved.

KW - Homeostasis

KW - Infection history

KW - Innate immunity

KW - Lung

KW - Secondary bacterial pneumonia

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DO - 10.1016/j.smim.2009.01.005

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EP - 155

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 3

ER -

Immune homeostasis in the respiratory tract and its impact on heterologous infection

Abstract

UN SDGs

Keywords

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