TY - JOUR
T1 - Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus
AU - Reynolds, Lisa A.
AU - Filbey, Kara J.
AU - Maizels, Rick M.
PY - 2012/10/11
Y1 - 2012/10/11
N2 - Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent model of the immunology of gastrointestinal helminth infections of humans and livestock. It is able to establish long-term chronic infections in many strains of mice, exerting potent immunomodulatory effects that dampen both protective immunity and bystander reactions to allergens and autoantigens. Immunity to the parasite develops naturally in some mouse strains and can be induced in others through immunization; while the mechanisms of protective immunity are not yet fully defined, both antibodies and a host cellular component are required, with strongest evidence for a role of alternatively activated macrophages. We discuss the balance between resistance and susceptibility in this model system and highlight new themes in innate and adaptive immunity, immunomodulation, and regulation of responsiveness in helminth infection.
AB - Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent model of the immunology of gastrointestinal helminth infections of humans and livestock. It is able to establish long-term chronic infections in many strains of mice, exerting potent immunomodulatory effects that dampen both protective immunity and bystander reactions to allergens and autoantigens. Immunity to the parasite develops naturally in some mouse strains and can be induced in others through immunization; while the mechanisms of protective immunity are not yet fully defined, both antibodies and a host cellular component are required, with strongest evidence for a role of alternatively activated macrophages. We discuss the balance between resistance and susceptibility in this model system and highlight new themes in innate and adaptive immunity, immunomodulation, and regulation of responsiveness in helminth infection.
UR - https://www.scopus.com/pages/publications/84876050140
U2 - 10.1007/s00281-012-0347-3
DO - 10.1007/s00281-012-0347-3
M3 - Review article
SN - 1863-2297
VL - 34
SP - 829
EP - 846
JO - Seminars in Immunopathology
JF - Seminars in Immunopathology
ER -