Immunogene therapy against mouse leukemia using B7 molecules

Tsuyoshi Takahashi, Naoto Hirano, Tokiharu Takahashi, Shigeru Chiba, Yoshio Yazaki, Hisamaru Hirai

    Research output: Contribution to journalArticlepeer-review

    Abstract

    B7 costimulatory molecules play an important role in T-cell activation. It is well known that tumor cells that express B7 molecules can elicit antitumor immunity, but little is known regarding which B7 molecule, B7-1 (CD80) or B7-2 (CD86), can do so more efficiently. To address this issue, we have introduced B7-1 or B7-2 into 8709 cells, a radiation-induced mouse myelocytic leukemic cell line, and have compared their potentials regarding the induction of antitumor immunity. Either B7-1- or B7-2-transduced monoclonal sublines, 8709/B7-1 or 8709/B7-2, respectively, diminished tumorigenicity in syngeneic C3H mice. Some reports have indicated that B7-1 is superior to B7-2 in the induction of antitumor immunity. Contrary to these results, the 8709/B7-2 lines are superior to the 8709/B7-1 lines in their capacity to induce antitumor immunity. In vivo depletion of lymphocyte subsets demonstrated that both CD4+ and CD8+ T cells were indispensable for B7-1- or B7-2-dependent antitumor immunity, whereas natural killer cells were not. These results suggest that in some circumstances, B7-2 molecule is more effective than B7-1 molecule in eliciting antitumor immunity.
    Original languageEnglish
    Pages (from-to)144-150
    Number of pages6
    JournalCancer Gene Therapy
    Volume7
    Issue number1
    DOIs
    Publication statusPublished - 2000

    Keywords

    • B7 molecules
    • Gene therapy
    • Leukemia

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