Immunogenetic factors in HPV-associated cervical cancer: Influence on disease progression

M. F. Duggan-Keen; P. J. Keating; F. R. A. Stevens; P. Sinnott; P. J. F. Snijders; J. M. M. Walboomers; S. Davidson; R. D. Hunter; P. A. Dyer; P. L. Stern

doi:10.1111/j.1744-313X.1996.tb00123.x

Immunogenetic factors in HPV-associated cervical cancer: Influence on disease progression

M. F. Duggan-Keen, P. J. Keating, F. R. A. Stevens, P. Sinnott, P. J. F. Snijders, J. M. M. Walboomers, S. Davidson, R. D. Hunter, P. A. Dyer, P. L. Stern

Research output: Contribution to journal › Article › peer-review

Abstract

No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB 1*1501/DQB 1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.

Original language	English
Pages (from-to)	275-284
Number of pages	10
Journal	European Journal of Immunogenetics
Volume	23
Issue number	4
DOIs	https://doi.org/10.1111/j.1744-313X.1996.tb00123.x
Publication status	Published - Aug 1996

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10.1111/j.1744-313X.1996.tb00123.x

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title = "Immunogenetic factors in HPV-associated cervical cancer: Influence on disease progression",

abstract = "No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB 1*1501/DQB 1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.",

author = "Duggan-Keen, {M. F.} and Keating, {P. J.} and Stevens, {F. R. A.} and P. Sinnott and Snijders, {P. J. F.} and Walboomers, {J. M. M.} and S. Davidson and Hunter, {R. D.} and Dyer, {P. A.} and Stern, {P. L.}",

year = "1996",

month = aug,

doi = "10.1111/j.1744-313X.1996.tb00123.x",

language = "English",

volume = "23",

pages = "275--284",

journal = "European Journal of Immunogenetics",

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TY - JOUR

T1 - Immunogenetic factors in HPV-associated cervical cancer

T2 - Influence on disease progression

AU - Duggan-Keen, M. F.

AU - Keating, P. J.

AU - Stevens, F. R. A.

AU - Sinnott, P.

AU - Snijders, P. J. F.

AU - Walboomers, J. M. M.

AU - Davidson, S.

AU - Hunter, R. D.

AU - Dyer, P. A.

AU - Stern, P. L.

PY - 1996/8

Y1 - 1996/8

N2 - No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB 1*1501/DQB 1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.

AB - No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB 1*1501/DQB 1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.

U2 - 10.1111/j.1744-313X.1996.tb00123.x

DO - 10.1111/j.1744-313X.1996.tb00123.x

M3 - Article

SN - 0960-7420

VL - 23

SP - 275

EP - 284

JO - European Journal of Immunogenetics

JF - European Journal of Immunogenetics

IS - 4

ER -

Immunogenetic factors in HPV-associated cervical cancer: Influence on disease progression

Abstract

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