Immunoregulation of skin sensitization and regulatory T cells

It is well established that, in common with other adaptive immune responses, the acquisition of skin sensitization is carefully orchestrated and finely controlled. This is achieved in a number of ways. However, in recent years, there has been an increasing interest in the roles that regulatory T cells (Tregs) play in allergic contact dermatitis. Here, we review briefly the phenotype and function of Tregs, and consider how they may impact on various aspects of skin sensitization, including: inter-individual differences in susceptibility; variations in the potency of chemical allergens; and the prevention of excessive, and potentially damaging, levels of sensitization. © 2012 John Wiley & Sons A/S.