Immunoregulation of skin sensitization and regulatory T cells

Ian Kimber, Mark A. Travis, Stefan F. Martin, Rebecca J. Dearman

    Research output: Contribution to journalArticlepeer-review


    It is well established that, in common with other adaptive immune responses, the acquisition of skin sensitization is carefully orchestrated and finely controlled. This is achieved in a number of ways. However, in recent years, there has been an increasing interest in the roles that regulatory T cells (Tregs) play in allergic contact dermatitis. Here, we review briefly the phenotype and function of Tregs, and consider how they may impact on various aspects of skin sensitization, including: inter-individual differences in susceptibility; variations in the potency of chemical allergens; and the prevention of excessive, and potentially damaging, levels of sensitization. © 2012 John Wiley & Sons A/S.
    Original languageEnglish
    Pages (from-to)179-183
    Number of pages4
    JournalContact dermatitis
    Issue number4
    Publication statusPublished - Oct 2012


    • immunoregulation
    • regulatory T cells
    • skin sensitization


    Dive into the research topics of 'Immunoregulation of skin sensitization and regulatory T cells'. Together they form a unique fingerprint.

    Cite this