Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort

Ben Parker; Murray B. Urowitz; Dafna D. Gladman; Mark Lunt; Rachelle Donn; Sang Cheol Bae; Jorge Sanchez-Guerrero; Juanita Romero-Diaz; Caroline Gordon; Daniel J. Wallace; Ann E. Clarke; Sasha Bernatsky; Ellen M. Ginzler; David A. Isenberg; Anisur Rahman; Joan T. Merrill; Graciela S. Alarcón; Barri J. Fessler; Paul R. Fortin; John G. Hanly; Michelle Petri; Kristjan Steinsson; Mary Anne Dooley; Susan Manzi; Munther A. Khamashta; Rosalind Ramsey-Goldman; Asad A. Zoma; Gunnar K. Sturfelt; Ola Nived; Cynthia Aranow; Meggan Mackay; Manuel Ramos-Casals; Ronald F. van Vollenhoven; Kenneth C. Kalunian; Guillermo Ruiz-Irastorza; S. Sam Lim; Diane L. Kamen; Christine A. Peschken; Murat Inanc; Ian N. Bruce

doi:10.1136/annrheumdis-2013-203933

Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort

Ben Parker, Murray B. Urowitz, Dafna D. Gladman, Mark Lunt, Rachelle Donn, Sang Cheol Bae, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Caroline Gordon, Daniel J. Wallace, Ann E. Clarke, Sasha Bernatsky, Ellen M. Ginzler, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Graciela S. Alarcón, Barri J. Fessler, Paul R. Fortin, John G. HanlyMichelle Petri, Kristjan Steinsson, Mary Anne Dooley, Susan Manzi, Munther A. Khamashta, Rosalind Ramsey-Goldman, Asad A. Zoma, Gunnar K. Sturfelt, Ola Nived, Cynthia Aranow, Meggan Mackay, Manuel Ramos-Casals, Ronald F. van Vollenhoven, Kenneth C. Kalunian, Guillermo Ruiz-Irastorza, S. Sam Lim, Diane L. Kamen, Christine A. Peschken, Murat Inanc, Ian N. Bruce

Division of Musculoskeletal & Dermatological Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE. Methods: Recently diagnosed (1, higher disease activity, increasing age and Hispanic or Black African race/ethnicity were independently associated with MetS over the first 2 years of follow-up in the cohort. Conclusions: MetS is a persistent phenotype in a significant proportion of patients with SLE. Renal lupus, active inflammatory disease and damage are SLE-related factors that drive MetS development while antimalarial agents appear to be protective from early in the disease course. © 2014 BMJ Publishing Group Ltd & European League Against Rheumatism.

Original language	English
Journal	Annals of the rheumatic diseases
DOIs	https://doi.org/10.1136/annrheumdis-2013-203933
Publication status	Published - 1 Apr 2014

Keywords

Cardiovascular Disease
Inflammation
Systemic Lupus Erythematosus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/annrheumdis-2013-203933

Arthritis Research UK Centre of Excellence in Epidemiology.
Symmons, D. (PI), Bruce, I. (CoI), Dixon, W. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI) & Verstappen, S. (CoI)
1/08/13 → 31/07/18
Project: Research

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Parker, B., Urowitz, M. B., Gladman, D. D., Lunt, M., Donn, R., Bae, S. C., Sanchez-Guerrero, J., Romero-Diaz, J., Gordon, C., Wallace, D. J., Clarke, A. E., Bernatsky, S., Ginzler, E. M., Isenberg, D. A., Rahman, A., Merrill, J. T., Alarcón, G. S., Fessler, B. J., Fortin, P. R., ... Bruce, I. N. (2014). Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort. Annals of the rheumatic diseases. https://doi.org/10.1136/annrheumdis-2013-203933

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title = "Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort",

abstract = "Background: The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE. Methods: Recently diagnosed (1, higher disease activity, increasing age and Hispanic or Black African race/ethnicity were independently associated with MetS over the first 2 years of follow-up in the cohort. Conclusions: MetS is a persistent phenotype in a significant proportion of patients with SLE. Renal lupus, active inflammatory disease and damage are SLE-related factors that drive MetS development while antimalarial agents appear to be protective from early in the disease course. {\textcopyright} 2014 BMJ Publishing Group Ltd & European League Against Rheumatism.",

keywords = "Cardiovascular Disease, Inflammation, Systemic Lupus Erythematosus",

author = "Ben Parker and Urowitz, {Murray B.} and Gladman, {Dafna D.} and Mark Lunt and Rachelle Donn and Bae, {Sang Cheol} and Jorge Sanchez-Guerrero and Juanita Romero-Diaz and Caroline Gordon and Wallace, {Daniel J.} and Clarke, {Ann E.} and Sasha Bernatsky and Ginzler, {Ellen M.} and Isenberg, {David A.} and Anisur Rahman and Merrill, {Joan T.} and Alarc{\'o}n, {Graciela S.} and Fessler, {Barri J.} and Fortin, {Paul R.} and Hanly, {John G.} and Michelle Petri and Kristjan Steinsson and Dooley, {Mary Anne} and Susan Manzi and Khamashta, {Munther A.} and Rosalind Ramsey-Goldman and Zoma, {Asad A.} and Sturfelt, {Gunnar K.} and Ola Nived and Cynthia Aranow and Meggan Mackay and Manuel Ramos-Casals and {van Vollenhoven}, {Ronald F.} and Kalunian, {Kenneth C.} and Guillermo Ruiz-Irastorza and Lim, {S. Sam} and Kamen, {Diane L.} and Peschken, {Christine A.} and Murat Inanc and Bruce, {Ian N.}",

year = "2014",

month = apr,

day = "1",

doi = "10.1136/annrheumdis-2013-203933",

language = "English",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "Elsevier BV",

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Parker, B, Urowitz, MB, Gladman, DD, Lunt, M , Donn, R, Bae, SC, Sanchez-Guerrero, J, Romero-Diaz, J, Gordon, C, Wallace, DJ, Clarke, AE, Bernatsky, S, Ginzler, EM, Isenberg, DA, Rahman, A, Merrill, JT, Alarcón, GS, Fessler, BJ, Fortin, PR, Hanly, JG, Petri, M, Steinsson, K, Dooley, MA, Manzi, S, Khamashta, MA, Ramsey-Goldman, R, Zoma, AA, Sturfelt, GK, Nived, O, Aranow, C, Mackay, M, Ramos-Casals, M, van Vollenhoven, RF, Kalunian, KC, Ruiz-Irastorza, G, Lim, SS, Kamen, DL, Peschken, CA, Inanc, M & Bruce, IN 2014, 'Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort', Annals of the rheumatic diseases. https://doi.org/10.1136/annrheumdis-2013-203933

TY - JOUR

T1 - Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort

AU - Parker, Ben

AU - Urowitz, Murray B.

AU - Gladman, Dafna D.

AU - Lunt, Mark

AU - Donn, Rachelle

AU - Bae, Sang Cheol

AU - Sanchez-Guerrero, Jorge

AU - Romero-Diaz, Juanita

AU - Gordon, Caroline

AU - Wallace, Daniel J.

AU - Clarke, Ann E.

AU - Bernatsky, Sasha

AU - Ginzler, Ellen M.

AU - Isenberg, David A.

AU - Rahman, Anisur

AU - Merrill, Joan T.

AU - Alarcón, Graciela S.

AU - Fessler, Barri J.

AU - Fortin, Paul R.

AU - Hanly, John G.

AU - Petri, Michelle

AU - Steinsson, Kristjan

AU - Dooley, Mary Anne

AU - Manzi, Susan

AU - Khamashta, Munther A.

AU - Ramsey-Goldman, Rosalind

AU - Zoma, Asad A.

AU - Sturfelt, Gunnar K.

AU - Nived, Ola

AU - Aranow, Cynthia

AU - Mackay, Meggan

AU - Ramos-Casals, Manuel

AU - van Vollenhoven, Ronald F.

AU - Kalunian, Kenneth C.

AU - Ruiz-Irastorza, Guillermo

AU - Lim, S. Sam

AU - Kamen, Diane L.

AU - Peschken, Christine A.

AU - Inanc, Murat

AU - Bruce, Ian N.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Background: The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE. Methods: Recently diagnosed (1, higher disease activity, increasing age and Hispanic or Black African race/ethnicity were independently associated with MetS over the first 2 years of follow-up in the cohort. Conclusions: MetS is a persistent phenotype in a significant proportion of patients with SLE. Renal lupus, active inflammatory disease and damage are SLE-related factors that drive MetS development while antimalarial agents appear to be protective from early in the disease course. © 2014 BMJ Publishing Group Ltd & European League Against Rheumatism.

AB - Background: The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE. Methods: Recently diagnosed (1, higher disease activity, increasing age and Hispanic or Black African race/ethnicity were independently associated with MetS over the first 2 years of follow-up in the cohort. Conclusions: MetS is a persistent phenotype in a significant proportion of patients with SLE. Renal lupus, active inflammatory disease and damage are SLE-related factors that drive MetS development while antimalarial agents appear to be protective from early in the disease course. © 2014 BMJ Publishing Group Ltd & European League Against Rheumatism.

KW - Cardiovascular Disease

KW - Inflammation

KW - Systemic Lupus Erythematosus

U2 - 10.1136/annrheumdis-2013-203933

DO - 10.1136/annrheumdis-2013-203933

M3 - Article

C2 - 24692585

SN - 0003-4967

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

ER -

Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort

Abstract

Keywords

UN SDGs

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Projects

Arthritis Research UK Centre of Excellence in Epidemiology.

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