Impact of glucose intolerance and insulin resistance on cardiac structure and function: Sex-related differences in the Framingham Heart Study

Martin K. Rutter; Helen Parise; Emelia J. Benjamin; Daniel Levy; Martin G. Larson; James B. Meigs; Richard W. Nesto; Peter W F Wilson; Ramachandran S. Vasan

doi:10.1161/01.CIR.0000045671.62860.98

Impact of glucose intolerance and insulin resistance on cardiac structure and function: Sex-related differences in the Framingham Heart Study

Martin K. Rutter, Helen Parise, Emelia J. Benjamin, Daniel Levy, Martin G. Larson, James B. Meigs, Richard W. Nesto, Peter W F Wilson, Ramachandran S. Vasan

Research output: Contribution to journal › Article › peer-review

Abstract

Background - Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias. Methods and Results - We examined the relations between echocardiographic LV measurements and glucose tolerance status in 2623 Framingham Study subjects (1514 women, mean age 53 years) free of myocardial infarction and heart failure. We also evaluated the relations of insulin resistance (homeostasis model, HOMA-IR) and LV and left atrial (LA) measures within the normal and abnormal glucose tolerance categories (the latter included impaired glucose tolerance, impaired fasting glucose, and newly diagnosed diabetes). LV mass (adjusted for age, height, heart rate, and systolic blood pressure) increased across categories of worsening glucose tolerance; the trend was more striking in women (P

Original language	English
Pages (from-to)	448-454
Number of pages	6
Journal	Circulation
Volume	107
Issue number	3
DOIs	https://doi.org/10.1161/01.CIR.0000045671.62860.98
Publication status	Published - 28 Jan 2003

Keywords

Echocardiography
Hypertrophy
Insulin
Ventricle, left
Ventricular

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1161/01.CIR.0000045671.62860.98

Cite this

@article{e55b73347a66447d8fc512f9277b4a40,

title = "Impact of glucose intolerance and insulin resistance on cardiac structure and function: Sex-related differences in the Framingham Heart Study",

abstract = "Background - Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias. Methods and Results - We examined the relations between echocardiographic LV measurements and glucose tolerance status in 2623 Framingham Study subjects (1514 women, mean age 53 years) free of myocardial infarction and heart failure. We also evaluated the relations of insulin resistance (homeostasis model, HOMA-IR) and LV and left atrial (LA) measures within the normal and abnormal glucose tolerance categories (the latter included impaired glucose tolerance, impaired fasting glucose, and newly diagnosed diabetes). LV mass (adjusted for age, height, heart rate, and systolic blood pressure) increased across categories of worsening glucose tolerance; the trend was more striking in women (P",

keywords = "Echocardiography, Hypertrophy, Insulin, Ventricle, left, Ventricular",

author = "Rutter, {Martin K.} and Helen Parise and Benjamin, {Emelia J.} and Daniel Levy and Larson, {Martin G.} and Meigs, {James B.} and Nesto, {Richard W.} and Wilson, {Peter W F} and Vasan, {Ramachandran S.}",

note = "1K24 HL04334, NHLBI NIH HHS, United States5R01-NS-17950, NINDS NIH HHS, United StatesN01-HC-25195, NHLBI NIH HHS, United States",

year = "2003",

month = jan,

day = "28",

doi = "10.1161/01.CIR.0000045671.62860.98",

language = "English",

volume = "107",

pages = "448--454",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams & Wilkins",

number = "3",

}

TY - JOUR

T1 - Impact of glucose intolerance and insulin resistance on cardiac structure and function: Sex-related differences in the Framingham Heart Study

AU - Rutter, Martin K.

AU - Parise, Helen

AU - Benjamin, Emelia J.

AU - Levy, Daniel

AU - Larson, Martin G.

AU - Meigs, James B.

AU - Nesto, Richard W.

AU - Wilson, Peter W F

AU - Vasan, Ramachandran S.

N1 - 1K24 HL04334, NHLBI NIH HHS, United States5R01-NS-17950, NINDS NIH HHS, United StatesN01-HC-25195, NHLBI NIH HHS, United States

PY - 2003/1/28

Y1 - 2003/1/28

N2 - Background - Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias. Methods and Results - We examined the relations between echocardiographic LV measurements and glucose tolerance status in 2623 Framingham Study subjects (1514 women, mean age 53 years) free of myocardial infarction and heart failure. We also evaluated the relations of insulin resistance (homeostasis model, HOMA-IR) and LV and left atrial (LA) measures within the normal and abnormal glucose tolerance categories (the latter included impaired glucose tolerance, impaired fasting glucose, and newly diagnosed diabetes). LV mass (adjusted for age, height, heart rate, and systolic blood pressure) increased across categories of worsening glucose tolerance; the trend was more striking in women (P

AB - Background - Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias. Methods and Results - We examined the relations between echocardiographic LV measurements and glucose tolerance status in 2623 Framingham Study subjects (1514 women, mean age 53 years) free of myocardial infarction and heart failure. We also evaluated the relations of insulin resistance (homeostasis model, HOMA-IR) and LV and left atrial (LA) measures within the normal and abnormal glucose tolerance categories (the latter included impaired glucose tolerance, impaired fasting glucose, and newly diagnosed diabetes). LV mass (adjusted for age, height, heart rate, and systolic blood pressure) increased across categories of worsening glucose tolerance; the trend was more striking in women (P

KW - Echocardiography

KW - Hypertrophy

KW - Insulin

KW - Ventricle, left

KW - Ventricular

U2 - 10.1161/01.CIR.0000045671.62860.98

DO - 10.1161/01.CIR.0000045671.62860.98

M3 - Article

C2 - 12551870

SN - 0009-7322

VL - 107

SP - 448

EP - 454

JO - Circulation

JF - Circulation

IS - 3

ER -

Impact of glucose intolerance and insulin resistance on cardiac structure and function: Sex-related differences in the Framingham Heart Study

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this