Abstract
Context: Pancreatic leak following pancreaticoduodenectomy has a major impact on postoperative mortality. However, it is not clear whether pancreatic leaks affect long term survival in patients with pancreatic ductal adenocarcinoma.
Objective: The aim of this study is to compare the long term outcome in patients who underwent pancreaticoduodenectomy, with and without postoperative pancreatic leak.
Patients: All 133 patients who underwent a pancreaticoduodenectomy at the HepatoPancreatoBiliary Unit, Addenbrooke's Hospital, Cambridge, between June 2002 and June 2007 were identified from a prospectively held database. The study was restricted to 47 patients who had a confirmed diagnosis of pancreatic ductal adenocarcinoma.
Setting: Pancreatic leak was defined as drain fluid amylase more than three times the serum level for more than 3 days post operatively.
Main outcome measure: Long term survival of patients with and without leaks were compared using Kaplan-Meier curves and significance was measured using the log-rank test.
Results: Median follow-up was 30.8 months. The median actuarial survival of all ductal adenocarcinoma patients was 19 months. Pancreatic leaks occurred in 9 patients (19.1%). There were no significant differences in the overall survival or presence of recurrence between the two groups.
Conclusions: Pancreatic leak following pancreaticoduodenectomy does not appear to impact on long-term outcome of patients with pancreatic ductal adenocarcinoma.
Objective: The aim of this study is to compare the long term outcome in patients who underwent pancreaticoduodenectomy, with and without postoperative pancreatic leak.
Patients: All 133 patients who underwent a pancreaticoduodenectomy at the HepatoPancreatoBiliary Unit, Addenbrooke's Hospital, Cambridge, between June 2002 and June 2007 were identified from a prospectively held database. The study was restricted to 47 patients who had a confirmed diagnosis of pancreatic ductal adenocarcinoma.
Setting: Pancreatic leak was defined as drain fluid amylase more than three times the serum level for more than 3 days post operatively.
Main outcome measure: Long term survival of patients with and without leaks were compared using Kaplan-Meier curves and significance was measured using the log-rank test.
Results: Median follow-up was 30.8 months. The median actuarial survival of all ductal adenocarcinoma patients was 19 months. Pancreatic leaks occurred in 9 patients (19.1%). There were no significant differences in the overall survival or presence of recurrence between the two groups.
Conclusions: Pancreatic leak following pancreaticoduodenectomy does not appear to impact on long-term outcome of patients with pancreatic ductal adenocarcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 226-229 |
| Number of pages | 4 |
| Journal | JOP : Journal of the pancreas |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 5 May 2010 |