Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study

Anders M. Greve; Eva Gerdts; Kurt Boman; Christa Gohlke-Baerwolf; Anne B. Rossebø; Richard B. Devereux; Lars Køber; Simon Ray; Ronnie Willenheimer; Kristian Wachtell

doi:10.1016/j.jacc.2011.12.020

Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study

Anders M. Greve, Eva Gerdts, Kurt Boman, Christa Gohlke-Baerwolf, Anne B. Rossebø, Richard B. Devereux, Lars Køber, Simon Ray, Ronnie Willenheimer, Kristian Wachtell

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: The aim of the study was to examine the predictive value of QRS duration and morphology during watchful waiting in asymptomatic patients with aortic stenosis (AS). Background: QRS duration and morphology are associated with poor prognosis in many different populations, but the predictive value, particularly of the risk of sudden cardiac death (SCD), in asymptomatic patients with AS has not been well studied. Methods: Data were obtained in asymptomatic AS patients randomized to simvastatin/ezetimibe combination versus placebo in the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study. The impact of QRS duration, evaluated as a categorical variable of

Original language	English
Pages (from-to)	1142-1149
Number of pages	7
Journal	Journal of the American College of Cardiology
Volume	59
Issue number	13
DOIs	https://doi.org/10.1016/j.jacc.2011.12.020
Publication status	Published - 27 Mar 2012

Keywords

asymptomatic aortic stenosis
QRS duration
sudden cardiac death

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10.1016/j.jacc.2011.12.020

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Greve, A. M., Gerdts, E., Boman, K., Gohlke-Baerwolf, C., Rossebø, A. B., Devereux, R. B., Køber, L., Ray, S., Willenheimer, R., & Wachtell, K. (2012). Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study. Journal of the American College of Cardiology, 59(13), 1142-1149. https://doi.org/10.1016/j.jacc.2011.12.020

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title = "Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study",

abstract = "Objectives: The aim of the study was to examine the predictive value of QRS duration and morphology during watchful waiting in asymptomatic patients with aortic stenosis (AS). Background: QRS duration and morphology are associated with poor prognosis in many different populations, but the predictive value, particularly of the risk of sudden cardiac death (SCD), in asymptomatic patients with AS has not been well studied. Methods: Data were obtained in asymptomatic AS patients randomized to simvastatin/ezetimibe combination versus placebo in the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study. The impact of QRS duration, evaluated as a categorical variable of",

keywords = "asymptomatic aortic stenosis, QRS duration, sudden cardiac death",

author = "Greve, {Anders M.} and Eva Gerdts and Kurt Boman and Christa Gohlke-Baerwolf and Rosseb{\o}, {Anne B.} and Devereux, {Richard B.} and Lars K{\o}ber and Simon Ray and Ronnie Willenheimer and Kristian Wachtell",

year = "2012",

month = mar,

day = "27",

doi = "10.1016/j.jacc.2011.12.020",

language = "English",

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journal = "Journal of the American College of Cardiology",

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Greve, AM, Gerdts, E, Boman, K, Gohlke-Baerwolf, C, Rossebø, AB, Devereux, RB, Køber, L, Ray, S, Willenheimer, R & Wachtell, K 2012, 'Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study', Journal of the American College of Cardiology, vol. 59, no. 13, pp. 1142-1149. https://doi.org/10.1016/j.jacc.2011.12.020

Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study. / Greve, Anders M.; Gerdts, Eva; Boman, Kurt et al.
In: Journal of the American College of Cardiology, Vol. 59, No. 13, 27.03.2012, p. 1142-1149.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study

AU - Greve, Anders M.

AU - Gerdts, Eva

AU - Boman, Kurt

AU - Gohlke-Baerwolf, Christa

AU - Rossebø, Anne B.

AU - Devereux, Richard B.

AU - Køber, Lars

AU - Ray, Simon

AU - Willenheimer, Ronnie

AU - Wachtell, Kristian

PY - 2012/3/27

Y1 - 2012/3/27

N2 - Objectives: The aim of the study was to examine the predictive value of QRS duration and morphology during watchful waiting in asymptomatic patients with aortic stenosis (AS). Background: QRS duration and morphology are associated with poor prognosis in many different populations, but the predictive value, particularly of the risk of sudden cardiac death (SCD), in asymptomatic patients with AS has not been well studied. Methods: Data were obtained in asymptomatic AS patients randomized to simvastatin/ezetimibe combination versus placebo in the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study. The impact of QRS duration, evaluated as a categorical variable of

AB - Objectives: The aim of the study was to examine the predictive value of QRS duration and morphology during watchful waiting in asymptomatic patients with aortic stenosis (AS). Background: QRS duration and morphology are associated with poor prognosis in many different populations, but the predictive value, particularly of the risk of sudden cardiac death (SCD), in asymptomatic patients with AS has not been well studied. Methods: Data were obtained in asymptomatic AS patients randomized to simvastatin/ezetimibe combination versus placebo in the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study. The impact of QRS duration, evaluated as a categorical variable of

KW - asymptomatic aortic stenosis

KW - QRS duration

KW - sudden cardiac death

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DO - 10.1016/j.jacc.2011.12.020

M3 - Article

C2 - 22440214

SN - 0735-1097

VL - 59

SP - 1142

EP - 1149

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

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ER -

Greve AM, Gerdts E, Boman K, Gohlke-Baerwolf C, Rossebø AB, Devereux RB et al. Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study. Journal of the American College of Cardiology. 2012 Mar 27;59(13):1142-1149. doi: 10.1016/j.jacc.2011.12.020

Impact of QRS duration and morphology on the risk of sudden cardiac death in asymptomatic patients with aortic stenosis: The SEAS (Simvastatin and ezetimibe in aortic stenosis) study

Abstract

Keywords

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