Abstract
Ornithine decarboxylase activity was measured in the dorsal root ganglia from crushed and uncrushed contralateral sciatic nerve of control and streptozotocin-diabetic rats. A further group of diabetic rats was treated with insulin throughout the experiment. Ornithine decarboxylase activity in ganglia from uncrushed nerves was the same in diabetic and non-diabetic rats. A significant (greater than 4-fold) increase in mean levels of ornithine decarboxylase activity 72 h after crush injury was found in ganglia from crushed nerves in non-diabetic but not in diabetic rats. The enzyme activity in ganglia from diabetic rats treated with insulin resembled that in non-diabetic rats. Twenty-four hours after crush injury, ornithine decarboxylase activity in ganglia from crushed nerves was higher in non-diabetic than in diabetic animals. This may be responsible for the delayed and defective nerve regeneration known to occur in peripheral nerve of the streptozotocin-diabetic rat. © 1987 Springer-Verlag.
| Original language | English |
|---|---|
| Pages (from-to) | 963-965 |
| Number of pages | 2 |
| Journal | Diabetologia |
| Volume | 30 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1987 |
Keywords
- diabetes mellitus
- nerve regeneration
- neuropathy
- ornithine decarboxylase
- Streptozotocin
