Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea

Rahul Yadav; Michael France; Reza Aghamohammadzadeh; Yifen Liu; Salam Hama; See Kwok; Jonathan Schofield; Peter Turkington; Akheel A. Syed; Rayaz Malik; Philip Pemberton; Adam Greenstein; Paul Durrington; Basil Ammori; Martin Gibson; Maria Jeziorska; Handrean Soran

doi:10.1210/jc.2013-3939

Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea

Rahul Yadav, Michael France, Reza Aghamohammadzadeh, Yifen Liu, Salam Hama, See Kwok, Jonathan Schofield, Peter Turkington, Akheel A. Syed, Rayaz Malik, Philip Pemberton, Adam Greenstein, Paul Durrington, Basil Ammori, Martin Gibson, Maria Jeziorska, Handrean Soran

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Abstract

© 2014 by the Endocrine Society.Design and Patients: Morbidly obese patients (n = 41) were divided into those whose apneahypoapnea index (AHI) was more or less than the median value and on the presence of OSA [OSA and no OSA (nOSA) groups]. We studied the antioxidant function of HDL and measured serum paraoxonase 1 (PON1) activity, TNFα, and intercellular adhesion molecule 1 (ICAM-1) levels in these patients. In a subset of 19 patients, we immunostained gluteal sc adipose tissue (SAT) for TNFα, macrophages, and measured adipocyte size.Results: HDL lipid peroxide levels were higher and serum PON1 activity was lower in the high AHI group vs the low AHI group (P

Original language	English
Pages (from-to)	3390-3398
Number of pages	8
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	99
Issue number	9
DOIs	https://doi.org/10.1210/jc.2013-3939
Publication status	Published - 1 Sept 2014

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Yadav, R., France, M., Aghamohammadzadeh, R., Liu, Y., Hama, S., Kwok, S., Schofield, J., Turkington, P., Syed, A. A., Malik, R., Pemberton, P., Greenstein, A., Durrington, P., Ammori, B., Gibson, M., Jeziorska, M., & Soran, H. (2014). Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea. Journal of Clinical Endocrinology and Metabolism, 99(9), 3390-3398. https://doi.org/10.1210/jc.2013-3939

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title = "Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea",

abstract = "{\textcopyright} 2014 by the Endocrine Society.Design and Patients: Morbidly obese patients (n = 41) were divided into those whose apneahypoapnea index (AHI) was more or less than the median value and on the presence of OSA [OSA and no OSA (nOSA) groups]. We studied the antioxidant function of HDL and measured serum paraoxonase 1 (PON1) activity, TNFα, and intercellular adhesion molecule 1 (ICAM-1) levels in these patients. In a subset of 19 patients, we immunostained gluteal sc adipose tissue (SAT) for TNFα, macrophages, and measured adipocyte size.Results: HDL lipid peroxide levels were higher and serum PON1 activity was lower in the high AHI group vs the low AHI group (P",

author = "Rahul Yadav and Michael France and Reza Aghamohammadzadeh and Yifen Liu and Salam Hama and See Kwok and Jonathan Schofield and Peter Turkington and Syed, {Akheel A.} and Rayaz Malik and Philip Pemberton and Adam Greenstein and Paul Durrington and Basil Ammori and Martin Gibson and Maria Jeziorska and Handrean Soran",

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doi = "10.1210/jc.2013-3939",

language = "English",

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Yadav, R, France, M, Aghamohammadzadeh, R, Liu, Y, Hama, S, Kwok, S, Schofield, J, Turkington, P, Syed, AA, Malik, R, Pemberton, P, Greenstein, A, Durrington, P, Ammori, B, Gibson, M, Jeziorska, M & Soran, H 2014, 'Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea', Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 9, pp. 3390-3398. https://doi.org/10.1210/jc.2013-3939

Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea. / Yadav, Rahul; France, Michael; Aghamohammadzadeh, Reza et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 9, 01.09.2014, p. 3390-3398.

Research output: Contribution to journal › Article › peer-review

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T1 - Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea

AU - Yadav, Rahul

AU - France, Michael

AU - Aghamohammadzadeh, Reza

AU - Liu, Yifen

AU - Hama, Salam

AU - Kwok, See

AU - Schofield, Jonathan

AU - Turkington, Peter

AU - Syed, Akheel A.

AU - Malik, Rayaz

AU - Pemberton, Philip

AU - Greenstein, Adam

AU - Durrington, Paul

AU - Ammori, Basil

AU - Gibson, Martin

AU - Jeziorska, Maria

AU - Soran, Handrean

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Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea

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