Improving phase-transfer catalysis by enhancing non-covalent interactions

Iñigo Iribarren, Cristina Trujillo

Research output: Contribution to journalArticlepeer-review

Abstract

A wide variety of asymmetric transformations catalysed by chiral catalysts have been developed for the synthesis of valuable organic compounds in the past several decades. Within the asymmetric catalysis field, phase-transfer catalysis has been recognized as a powerful method for establishing useful procedures for organic synthesis. In the present study intermolecular interactions between a well-known alkaloid quinine-derived phase transfer catalyst and four different anions were characterised, analysing the competition between the pure ion-pair interaction and the intermolecular hydrogen bond established upon complexation. Finally, a theoretical study of the free-energy profile corresponding to the enantioselective conjugate cyanation of an α,β-unsaturated ketone in the presence of two different catalysts was performed.

Original languageEnglish
Pages (from-to)21015-21021
Number of pages7
Journal Physical Chemistry Chemical Physics
Volume22
Issue number37
Early online date8 Jul 2020
DOIs
Publication statusPublished - 7 Oct 2020

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