Improving pulse sequences for 3D diffusion-ordered NMR spectroscopy: 2DJ-IDOSY

Mathias Nilsson, Ana M. Gil, Ivonne Delgadillo, Gareth A. Morris

    Research output: Contribution to journalArticlepeer-review


    An improved pulse sequence for the 3D DOSY experiment 2DJ-DOSY, using diffusion encoding internal to the parent 2DJ spectroscopy sequence (2DJ-IDOSY), is presented. The diffusion-encoding pulses are used to enforce the desired coherence transfer pathway, reducing the minimum experimental time by at least a factor of 4, as compared to existing techniques, and approximately doubling the signal-to-noise ratio for small molecules. The new sequence is demonstrated on a simple mixture and on a complex sample with a high dynamic range (port wine). The principle of internal diffusion encoding can be applied with profit to a range of other 3D DOSY experiments.
    Original languageEnglish
    Pages (from-to)5418-5422
    Number of pages4
    JournalAnalytical Chemistry
    Issue number18
    Publication statusPublished - 15 Sept 2004


    • Mathematical methods; NMR spectroscopy; Simulation and Modeling; Wine analysis (improving pulse sequences for 3D diffusion-ordered NMR spectroscopy)


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