In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians

Leonor Nogueira, Martin Cornillet, Madeleine Singwe-Ngandeu, Sebastien Viatte, Sylvette Bas, Cem Gabay, Guy Serre

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Well documented in Caucasians and Asians, the diagnostic value of anti-CCP2 antibodies has been confirmed in Black African populations. However, autoantibodies to other citrullinated peptides/proteins and their fine specificities have not yet been studied. Here, we show that in Cameroonian patients, anti-citrullinated fibrinogen autoantibodies (AhFibA) are sensitive (73%) diagnostic markers for RA. We also determine that autoantibodies directed to α36-50Cit38,42 or β60-74Cit60,72,74 peptides which bear the immunodominant epitopes of citrullinated fibrin, are present in similar proportions in Black Africans and Caucasians with 25/56 (45%) and 41/56 (73%) positive RA-sera in Cameroonians, respectively. They also account for almost all the AhFibA reactivities since 38/41 (93%) AhFibA-positive sera contain anti-α36-50Cit38,42 and/or anti-β60-74Cit60,72,74 autoantibodies. Finally, HLA-DRB1 SE alleles were associated with higher titres of AhFibA and anti-β60-74Cit60,72,74 autoantibodies. In the genetic and environmental backgrounds of Black Africans, AhFibA are a hallmark of RA like in Caucasians, moreover they recognize the same fibrin epitopes. © 2014 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)58-64
    Number of pages6
    JournalClinical Immunology
    Volume152
    Issue number1-2
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Anti-citrullinated protein autoantibodies (ACPA)
    • B-cell epitopes
    • Black Africans
    • Citrullinated fibrin
    • Rheumatoid arthritis

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