In situ-gelling gellan formulations as vehicles for oral drug delivery

Shozo Miyazaki, Hirotatsu Aoyama, Naoko Kawasaki, Wataru Kubo, David Attwood

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Gels formed in situ following oral administration of 1% (w/v) aqueous solutions of gellan to rats and rabbits were evaluated as sustained-release vehicles. The formulation contained calcium ions in complexed form, the release of which in the acidic environment of the stomach caused gelation of the gellan gum. The in vitro release of theophylline from the rigid gellan gels followed root-time kinetics over a period of 6 h. Plasma levels of theophylline after oral administration of gellan solutions and a commercial oral sustained-release liquid dosage form containing an identical drug concentration were compared in both rats and rabbits. Bioavailability of theophylline from gellan gels formed by in situ gelation in the animal stomach was increased by four-fivefold in rats and threefold in rabbits compared with that from the commercial oral formulation. There was no significant difference in the mean residence times of theophylline when administered by these two vehicles. Copyright (C) 1999 Elsevier Science B.V.
    Original languageEnglish
    Title of host publicationJournal of Controlled Release|J. Control. Release
    Pages287-295
    Number of pages8
    Volume60
    DOIs
    Publication statusPublished - 5 Aug 1999

    Keywords

    • Gellan gels
    • In situ gelation
    • Oral drug delivery
    • Sustained release
    • Theophylline

    Fingerprint

    Dive into the research topics of 'In situ-gelling gellan formulations as vehicles for oral drug delivery'. Together they form a unique fingerprint.

    Cite this