In situ-gelling gellan formulations as vehicles for oral drug delivery

Shozo Miyazaki, Hirotatsu Aoyama, Naoko Kawasaki, Wataru Kubo, David Attwood

    Research output: Chapter in Book/Report/Conference proceedingConference contribution


    Gels formed in situ following oral administration of 1% (w/v) aqueous solutions of gellan to rats and rabbits were evaluated as sustained-release vehicles. The formulation contained calcium ions in complexed form, the release of which in the acidic environment of the stomach caused gelation of the gellan gum. The in vitro release of theophylline from the rigid gellan gels followed root-time kinetics over a period of 6 h. Plasma levels of theophylline after oral administration of gellan solutions and a commercial oral sustained-release liquid dosage form containing an identical drug concentration were compared in both rats and rabbits. Bioavailability of theophylline from gellan gels formed by in situ gelation in the animal stomach was increased by four-fivefold in rats and threefold in rabbits compared with that from the commercial oral formulation. There was no significant difference in the mean residence times of theophylline when administered by these two vehicles. Copyright (C) 1999 Elsevier Science B.V.
    Original languageEnglish
    Title of host publicationJournal of Controlled Release|J. Control. Release
    Number of pages8
    Publication statusPublished - 5 Aug 1999


    • Gellan gels
    • In situ gelation
    • Oral drug delivery
    • Sustained release
    • Theophylline


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