In situ monitoring of chondrocyte response to bioactive scaffolds using Raman spectroscopy

Julian R. Jones, Archana Vats, Ioan Notingher, Julie E. Gough, Neil S. Tolley, Julia M. Polak, Larry L. Hench

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Septal cartilage is widely used for the repair of soft tissue defects in the head, neck and nose. Tissue Engineering techniques are being investigated to create cartilage in vitro by seeding appropriate cells on resorbable scaffolds. In this study, human chondrocytes, were cultured on macroporous bioactive glass foam scaffolds. The aim was to investigate how Raman spectrbscopy could be used as a non-invasive technique to monitor the response of chondrocytes to a 3D scaffold in real time. The spectra were compared to scanning electron microscope (SEM) micrographs and immunohistochemistry results.
    Original languageEnglish
    Pages (from-to)623-626
    Number of pages3
    JournalKey Engineering Materials
    Volume284-286
    DOIs
    Publication statusPublished - 2005

    Keywords

    • Bioactive glass
    • Cartilage
    • Chondrocytes
    • Raman spectroscopy
    • Scaffolds

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