In vitro activity of saperconazole (R66 905) compared with amphotericin B and itraconazole against Aspergillus species

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Abstract

Twenty isolates of aspergillus were tested against saperconazole and 16 of these against itraconazole and amphotericin B using a macrodilution broth method. For 18 (90 %) of 20isolates tested against saperconazole, MICs were ≤3.1 mg/l and for 15 (75 %) of 20 isolates MFCs were ≤3.1 mg/l. For 9 (56 %) of 16 isolates tested against itraconazole, MICs were ≤3.1 mg/l, and for 4 (33 %) of 12 isolates MFCs were ≤3.1 mg/l. For all 16 isolates tested against amphotericin B MICs and MFCs were ≤4.0 mg/l; for 11 of 16 isolates MICs were ≤2.0 mg/l. Saperconazole appears to be highly active againstAspergillus spp. in vitro, with a bimodal distribution of MICs and MFCs.

Original languageEnglish
Pages (from-to)693-697
Number of pages1
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Jan 1991

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