In-vitro activity of voriconazole against Aspergillus spp. and comparison with itraconazole and amphotericin B

K. L. Oakley, C. B. Moore, D. W. Denning

Research output: Contribution to journalArticlepeer-review

Abstract

The in-vitro activity of the triazole antifungal agent voriconazole was compared with itraconazole and amphotericin B against 60 aspergillus isolates. Susceptibility tests were performed using two methods: a macrodilution and a microdilution method. For macrodilution methodology, geometric mean (GM) MIC values and ranges were 0.4 and 0.125-4 mg/L for voriconazole, 0.24 and 0.06->16 mg/L for itraconazole, and 1.04 and 0.5-4 mg/L for amphotericin B. For the microdilution method, GM MICs and ranges were 0.66 and 0.125-2 mg/L for voriconazole, 0.27 and 0.06->16 mg/L for itraconazole, and 1.62 and 0.25-32 mg/L for amphotericin B. In conclusion, voriconazole is active against Aspergillus spp. in vitro, and at similar concentrations to itraconazole.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume42
Issue number1
DOIs
Publication statusPublished - 1 Jul 1998

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