In vitro evaluation of pectin-based colonic drug delivery systems

Zoë Wakerly; John T. Fell; David Attwood; David A. Parkins

doi:10.1016/0378-5173(95)04251-2

In vitro evaluation of pectin-based colonic drug delivery systems

Zoë Wakerly, John T. Fell, David Attwood, David A. Parkins

Research output: Contribution to journal › Article › peer-review

Abstract

Pectin-based dosage forms with the potential for site-specific delivery to the colon have been evaluated using isolated enzymes and cultures of Bacteroides ovatus. The system used was designed and validated to allow systematic testing of colonic dosage forms which depend on the action of colonic bacteria for drug release. Preliminary experiments show the similarity in release patterns for the dosage form tested with isolated enzymes and bacterial cultures. This should enable further experiments to be performed to ascertain valid in vitro testing conditions.

Original language	English
Pages (from-to)	73-77
Number of pages	4
Journal	International Journal of Pharmaceutics
Volume	129
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5173(95)04251-2
Publication status	Published - 8 Mar 1996

Keywords

Bacteroids ovatus
Colonic dosage form evaluation
Colonic drug delivery
Pectin

Access to Document

10.1016/0378-5173(95)04251-2

Cite this

@article{63b3176b374742658b40b294e2a70034,

title = "In vitro evaluation of pectin-based colonic drug delivery systems",

abstract = "Pectin-based dosage forms with the potential for site-specific delivery to the colon have been evaluated using isolated enzymes and cultures of Bacteroides ovatus. The system used was designed and validated to allow systematic testing of colonic dosage forms which depend on the action of colonic bacteria for drug release. Preliminary experiments show the similarity in release patterns for the dosage form tested with isolated enzymes and bacterial cultures. This should enable further experiments to be performed to ascertain valid in vitro testing conditions.",

keywords = "Bacteroids ovatus, Colonic dosage form evaluation, Colonic drug delivery, Pectin",

author = "Zo{\"e} Wakerly and Fell, {John T.} and David Attwood and Parkins, {David A.}",

year = "1996",

month = mar,

day = "8",

doi = "10.1016/0378-5173(95)04251-2",

language = "English",

volume = "129",

pages = "73--77",

journal = "International Journal of Pharmaceutics",

issn = "1873-3476",

publisher = "Elsevier BV",

number = "1-2",

}

TY - JOUR

T1 - In vitro evaluation of pectin-based colonic drug delivery systems

AU - Wakerly, Zoë

AU - Fell, John T.

AU - Attwood, David

AU - Parkins, David A.

PY - 1996/3/8

Y1 - 1996/3/8

N2 - Pectin-based dosage forms with the potential for site-specific delivery to the colon have been evaluated using isolated enzymes and cultures of Bacteroides ovatus. The system used was designed and validated to allow systematic testing of colonic dosage forms which depend on the action of colonic bacteria for drug release. Preliminary experiments show the similarity in release patterns for the dosage form tested with isolated enzymes and bacterial cultures. This should enable further experiments to be performed to ascertain valid in vitro testing conditions.

AB - Pectin-based dosage forms with the potential for site-specific delivery to the colon have been evaluated using isolated enzymes and cultures of Bacteroides ovatus. The system used was designed and validated to allow systematic testing of colonic dosage forms which depend on the action of colonic bacteria for drug release. Preliminary experiments show the similarity in release patterns for the dosage form tested with isolated enzymes and bacterial cultures. This should enable further experiments to be performed to ascertain valid in vitro testing conditions.

KW - Bacteroids ovatus

KW - Colonic dosage form evaluation

KW - Colonic drug delivery

KW - Pectin

U2 - 10.1016/0378-5173(95)04251-2

DO - 10.1016/0378-5173(95)04251-2

M3 - Article

SN - 1873-3476

VL - 129

SP - 73

EP - 77

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

In vitro evaluation of pectin-based colonic drug delivery systems

Abstract

Keywords

Access to Document

Fingerprint

Cite this