In-vitro resistance to imidazole antifungals in Candida albicans

E. M. Johnson, M. D. Richardson, D. W. Warnock

    Research output: Contribution to journalArticlepeer-review


    Three strains of Candida albicans from patients with chronic mucocutaneous candidosis (CMC) who relapsed during prolonged treatment with ketoconazole were compared with three other Can. albicans strains by means of an agar incorporation MIC method, a broth microdilution method for IC30 determination, and a hyphal elongation assessment method. The MICs of ketoconazole, tioconazole and miconazole were difficult to interpret, but were much higher for the three CMC strains if low inoculum concentrations and short incubation times were used. The IC50s of the three imidazoles were much higher for the CMC strains than for the others. The imidazoles all caused minimal inhibition of hyphal elongation by the three CMC strains at concentrations up to 50 mg/l. Concentrations of 0.5 mg/l caused marked inhibition of the other strains.
    Original languageEnglish
    Pages (from-to)547-558
    Number of pages11
    JournalJournal of Antimicrobial Chemotherapy
    Issue number6
    Publication statusPublished - 1984


    Dive into the research topics of 'In-vitro resistance to imidazole antifungals in Candida albicans'. Together they form a unique fingerprint.

    Cite this