In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection

Hugo Farne; Lijing Lin; David J. Jackson; Magnus Rattray; Angela Simpson; Adnan Custovic; Shilpy Joshi; Paul A. Wilson; Rick Williamson; Michael R. Edwards; Aran Singanayagam; Sebastian L. Johnston

doi:10.1136/thoraxjnl-2021-217389

In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection

Hugo Farne, Lijing Lin, David J. Jackson, Magnus Rattray, Angela Simpson, Adnan Custovic, Shilpy Joshi, Paul A. Wilson, Rick Williamson, Michael R. Edwards, Aran Singanayagam, Sebastian L. Johnston^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Despite good evidence of impaired innate antiviral responses in asthma, trials of inhaled interferon-β given during exacerbations showed only modest benefits in moderate/severe asthma. Using human experimental rhinovirus infection, we observe robust in vivo induction of bronchial epithelial interferon response genes 4 days after virus inoculation in 25 subjects with asthma but not 11 control subjects. This signature correlated with virus loads and lower respiratory symptoms. Our data indicate that the in vivo innate antiviral response is dysregulated in asthma and open up the potential that prophylactic rather than therapeutic interferon therapy may have greater clinical benefit.

Original language	English
Pages (from-to)	929-932
Number of pages	4
Journal	Thorax
Volume	77
Issue number	9
DOIs	https://doi.org/10.1136/thoraxjnl-2021-217389
Publication status	Published - 1 Sept 2022

Keywords

Asthma
Asthma Mechanisms
Innate Immunity
Viral infection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/thoraxjnl-2021-217389

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Farne, H., Lin, L., Jackson, D. J., Rattray, M., Simpson, A., Custovic, A., Joshi, S., Wilson, P. A., Williamson, R., Edwards, M. R., Singanayagam, A., & Johnston, S. L. (2022). In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection. Thorax, 77(9), 929-932. https://doi.org/10.1136/thoraxjnl-2021-217389

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abstract = "Despite good evidence of impaired innate antiviral responses in asthma, trials of inhaled interferon-β given during exacerbations showed only modest benefits in moderate/severe asthma. Using human experimental rhinovirus infection, we observe robust in vivo induction of bronchial epithelial interferon response genes 4 days after virus inoculation in 25 subjects with asthma but not 11 control subjects. This signature correlated with virus loads and lower respiratory symptoms. Our data indicate that the in vivo innate antiviral response is dysregulated in asthma and open up the potential that prophylactic rather than therapeutic interferon therapy may have greater clinical benefit.",

keywords = "Asthma, Asthma Mechanisms, Innate Immunity, Viral infection",

author = "Hugo Farne and Lijing Lin and Jackson, {David J.} and Magnus Rattray and Angela Simpson and Adnan Custovic and Shilpy Joshi and Wilson, {Paul A.} and Rick Williamson and Edwards, {Michael R.} and Aran Singanayagam and Johnston, {Sebastian L.}",

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T1 - In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection

AU - Farne, Hugo

AU - Lin, Lijing

AU - Jackson, David J.

AU - Rattray, Magnus

AU - Simpson, Angela

AU - Custovic, Adnan

AU - Joshi, Shilpy

AU - Wilson, Paul A.

AU - Williamson, Rick

AU - Edwards, Michael R.

AU - Singanayagam, Aran

AU - Johnston, Sebastian L.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Despite good evidence of impaired innate antiviral responses in asthma, trials of inhaled interferon-β given during exacerbations showed only modest benefits in moderate/severe asthma. Using human experimental rhinovirus infection, we observe robust in vivo induction of bronchial epithelial interferon response genes 4 days after virus inoculation in 25 subjects with asthma but not 11 control subjects. This signature correlated with virus loads and lower respiratory symptoms. Our data indicate that the in vivo innate antiviral response is dysregulated in asthma and open up the potential that prophylactic rather than therapeutic interferon therapy may have greater clinical benefit.

AB - Despite good evidence of impaired innate antiviral responses in asthma, trials of inhaled interferon-β given during exacerbations showed only modest benefits in moderate/severe asthma. Using human experimental rhinovirus infection, we observe robust in vivo induction of bronchial epithelial interferon response genes 4 days after virus inoculation in 25 subjects with asthma but not 11 control subjects. This signature correlated with virus loads and lower respiratory symptoms. Our data indicate that the in vivo innate antiviral response is dysregulated in asthma and open up the potential that prophylactic rather than therapeutic interferon therapy may have greater clinical benefit.

KW - Asthma

KW - Asthma Mechanisms

KW - Innate Immunity

KW - Viral infection

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U2 - 10.1136/thoraxjnl-2021-217389

DO - 10.1136/thoraxjnl-2021-217389

M3 - Article

C2 - 35790388

AN - SCOPUS:85134687452

SN - 0040-6376

VL - 77

SP - 929

EP - 932

JO - Thorax

JF - Thorax

IS - 9

ER -

In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection

Abstract

Keywords

UN SDGs

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