In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection

Hugo Farne, Lijing Lin, David J. Jackson, Magnus Rattray, Angela Simpson, Adnan Custovic, Shilpy Joshi, Paul A. Wilson, Rick Williamson, Michael R. Edwards, Aran Singanayagam, Sebastian L. Johnston

Research output: Contribution to journalArticlepeer-review

Abstract

Despite good evidence of impaired innate antiviral responses in asthma, trials of inhaled interferon-β given during exacerbations showed only modest benefits in moderate/severe asthma. Using human experimental rhinovirus infection, we observe robust in vivo induction of bronchial epithelial interferon response genes 4 days after virus inoculation in 25 subjects with asthma but not 11 control subjects. This signature correlated with virus loads and lower respiratory symptoms. Our data indicate that the in vivo innate antiviral response is dysregulated in asthma and open up the potential that prophylactic rather than therapeutic interferon therapy may have greater clinical benefit.

Original languageEnglish
Pages (from-to)929-932
Number of pages4
JournalThorax
Volume77
Issue number9
DOIs
Publication statusPublished - 1 Sept 2022

Keywords

  • Asthma
  • Asthma Mechanisms
  • Innate Immunity
  • Viral infection

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