In vivo cell reprogramming to pluripotency: exploring a novel tool for cell replenishment and tissue regeneration

de Lázaro, K Kostarelos

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The potential of cell-replacement strategies for the treatment of disorders in which a particular cell type is damaged or degenerated has prompted the search for the perfect cell source. iPSCs (induced pluripotent stem cells) stand out as very advantageous candidates thanks to their self-renewal capacity and differentiation potential, together with the possibility of generating them from autologous somatic cells with minimally invasive techniques. However, their differentiation into the required cell type, precise delivery and successful engraftment and survival in the host are still challenging subjects. We have proposed the transient reprogramming of somatic cells towards a pluripotent state in their in vivo microenvironment as a means to facilitate the regeneration of the tissue. The initial reports of in vivo reprogramming to pluripotency in the literature are reviewed and the potential clinical applications of this strategy are discussed.
    Original languageEnglish
    JournalBiochemical Society. Transactions
    Volume42
    Issue number3
    DOIs
    Publication statusPublished - 2014

    Fingerprint

    Dive into the research topics of 'In vivo cell reprogramming to pluripotency: exploring a novel tool for cell replenishment and tissue regeneration'. Together they form a unique fingerprint.

    Cite this