In vivo dehydration of silicone hydrogel contact lenses

Philip B. Morgan, Nathan Efron

    Research output: Contribution to journalArticlepeer-review


    Purpose. To benchmark the performance of new-generation silicone hydrogel contact lenses in terms of their in vivo hydration characteristics and to highlight the possible clinical ramifications of any changes observed. Methods. Thirteen subjects (four men and nine women with a mean age of 24.8 ± 5.0 years) wore a silicone hydrogel lens (PureVision, Bausch & Lomb, Rochester, NY) in one eye and a conventional hydrogel lens (ACUVUE 2, Johnson & Johnson Vision Care, Jacksonville, FL) in the other eye for 4 weeks on an extended-wear basis. A gravimetric method was used to determine lens water content and dehydration during the intended lifespan of the lenses. Results. For the PureVision lens, the water content was 38.3% ± 0.9%, 35.2% ± 1.1%, and 35.3% ± 1.7% at baseline and after 2 and 4 weeks of wear, respectively (F=28.4, P
    Original languageEnglish
    Pages (from-to)173-176
    Number of pages3
    JournalEye and Contact Lens
    Issue number3
    Publication statusPublished - Jul 2003


    • Dehydration
    • Deposition
    • Hydrogel contact lens
    • Silicone hydrogel contact lens
    • Water content


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