TY - JOUR
T1 - In vivo investigation of 3D printed polycaprolactone/graphene electro-active bone scaffolds
AU - Lopes Nalesso, Paulo Roberto
AU - Hou, Yanhao
AU - Bagne, Leonardo
AU - Pereira, Amanda
AU - Helaehil, Julia
AU - Andrade, Thiago Antônio
AU - Chiarotto, Gabriela
AU - Da Silva Bartolo, Paulo Jorge
AU - Caetano, Guilherme
A2 - Wang, Weiguang
PY - 2021/7/26
Y1 - 2021/7/26
N2 - Additive manufactured scaffolds are widely used as 3D support structures for tissue engineering. This paper investigates the mechanisms behind bone regeneration due to the combined use of 3D printed poly(ɛ-caprolactone)/graphene (PCL/G) electro-active scaffolds and electrical stimulation. A comprehensive in vivo study was conducted to assess the proposed approach, using a rat model. Results show that the combined use of electro-active scaffolds and electrical stimulation therapy accelerates the bone regeneration process and the formation of more organised new bone, through fast angiogenesis, and a rapid transition to the mineralisation and bone remodelling phase. The mechanism is investigated and explained.
AB - Additive manufactured scaffolds are widely used as 3D support structures for tissue engineering. This paper investigates the mechanisms behind bone regeneration due to the combined use of 3D printed poly(ɛ-caprolactone)/graphene (PCL/G) electro-active scaffolds and electrical stimulation. A comprehensive in vivo study was conducted to assess the proposed approach, using a rat model. Results show that the combined use of electro-active scaffolds and electrical stimulation therapy accelerates the bone regeneration process and the formation of more organised new bone, through fast angiogenesis, and a rapid transition to the mineralisation and bone remodelling phase. The mechanism is investigated and explained.
M3 - Article
SN - 2405-8866
JO - Bioprinting
JF - Bioprinting
ER -