In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Amin Rostami-Hochaghan; Erik Sjögren; Bertil Abrahamsson; Patrick Augustijns; Dieter Becker; Michael B. Bolger; Marcus Brewster; Joachim Brouwers; Talia Flanagan; Matthew Harwood; Christian Heinen; René Holm; Hans Paul Juretschke; Marlies Kubbinga; Anders Lindahl; Viera Lukacova; Uwe Münster; Sibylle Neuhoff; Mai Anh Nguyen; Achiel Van Peer; Christos Reppas; Amin Rostami Hodjegan; Christer Tannergren; Werner Weitschies; Clive Wilson; Patricia Zane; Hans Lennernäs; Peter Langguth

doi:10.1016/j.ejps.2014.02.010

In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Amin Rostami-Hochaghan, Erik Sjögren, Bertil Abrahamsson, Patrick Augustijns, Dieter Becker, Michael B. Bolger, Marcus Brewster, Joachim Brouwers, Talia Flanagan, Matthew Harwood, Christian Heinen, René Holm, Hans Paul Juretschke, Marlies Kubbinga, Anders Lindahl, Viera Lukacova, Uwe Münster, Sibylle Neuhoff, Mai Anh Nguyen, Achiel Van PeerChristos Reppas, Amin Rostami Hodjegan, Christer Tannergren, Werner Weitschies, Clive Wilson, Patricia Zane, Hans Lennernäs, Peter Langguth

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing. © 2013 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	99-151
Number of pages	52
Journal	European Journal of Pharmaceutical Sciences
Volume	57
Issue number	1
DOIs	https://doi.org/10.1016/j.ejps.2014.02.010
Publication status	Published - 16 Jun 2014

Keywords

Bioavailability
Biopharmaceutic characterization
Drug product development
In vivo model selection

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Rostami-Hochaghan, A., Sjögren, E., Abrahamsson, B., Augustijns, P., Becker, D., Bolger, M. B., Brewster, M., Brouwers, J., Flanagan, T., Harwood, M., Heinen, C., Holm, R., Juretschke, H. P., Kubbinga, M., Lindahl, A., Lukacova, V., Münster, U., Neuhoff, S., Nguyen, M. A., ... Langguth, P. (2014). In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences, 57(1), 99-151. https://doi.org/10.1016/j.ejps.2014.02.010

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title = "In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects",

abstract = "This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing. {\textcopyright} 2013 Elsevier B.V. All rights reserved.",

keywords = "Bioavailability, Biopharmaceutic characterization, Drug product development, In vivo model selection",

author = "Amin Rostami-Hochaghan and Erik Sj{\"o}gren and Bertil Abrahamsson and Patrick Augustijns and Dieter Becker and Bolger, {Michael B.} and Marcus Brewster and Joachim Brouwers and Talia Flanagan and Matthew Harwood and Christian Heinen and Ren{\'e} Holm and Juretschke, {Hans Paul} and Marlies Kubbinga and Anders Lindahl and Viera Lukacova and Uwe M{\"u}nster and Sibylle Neuhoff and Nguyen, {Mai Anh} and Peer, {Achiel Van} and Christos Reppas and {Rostami Hodjegan}, Amin and Christer Tannergren and Werner Weitschies and Clive Wilson and Patricia Zane and Hans Lennern{\"a}s and Peter Langguth",

year = "2014",

month = jun,

day = "16",

doi = "10.1016/j.ejps.2014.02.010",

language = "English",

volume = "57",

pages = "99--151",

journal = "European Journal of Pharmaceutical Sciences",

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Rostami-Hochaghan, A, Sjögren, E, Abrahamsson, B, Augustijns, P, Becker, D, Bolger, MB, Brewster, M, Brouwers, J, Flanagan, T, Harwood, M, Heinen, C, Holm, R, Juretschke, HP, Kubbinga, M, Lindahl, A, Lukacova, V, Münster, U, Neuhoff, S, Nguyen, MA, Peer, AV, Reppas, C, Rostami Hodjegan, A, Tannergren, C, Weitschies, W, Wilson, C, Zane, P, Lennernäs, H & Langguth, P 2014, 'In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects', European Journal of Pharmaceutical Sciences, vol. 57, no. 1, pp. 99-151. https://doi.org/10.1016/j.ejps.2014.02.010

In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. / Rostami-Hochaghan, Amin; Sjögren, Erik; Abrahamsson, Bertil et al.
In: European Journal of Pharmaceutical Sciences, Vol. 57, No. 1, 16.06.2014, p. 99-151.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

AU - Rostami-Hochaghan, Amin

AU - Sjögren, Erik

AU - Abrahamsson, Bertil

AU - Augustijns, Patrick

AU - Becker, Dieter

AU - Bolger, Michael B.

AU - Brewster, Marcus

AU - Brouwers, Joachim

AU - Flanagan, Talia

AU - Harwood, Matthew

AU - Heinen, Christian

AU - Holm, René

AU - Juretschke, Hans Paul

AU - Kubbinga, Marlies

AU - Lindahl, Anders

AU - Lukacova, Viera

AU - Münster, Uwe

AU - Neuhoff, Sibylle

AU - Nguyen, Mai Anh

AU - Peer, Achiel Van

AU - Reppas, Christos

AU - Rostami Hodjegan, Amin

AU - Tannergren, Christer

AU - Weitschies, Werner

AU - Wilson, Clive

AU - Zane, Patricia

AU - Lennernäs, Hans

AU - Langguth, Peter

PY - 2014/6/16

Y1 - 2014/6/16

N2 - This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing. © 2013 Elsevier B.V. All rights reserved.

AB - This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing. © 2013 Elsevier B.V. All rights reserved.

KW - Bioavailability

KW - Biopharmaceutic characterization

KW - Drug product development

KW - In vivo model selection

U2 - 10.1016/j.ejps.2014.02.010

DO - 10.1016/j.ejps.2014.02.010

M3 - Article

SN - 0928-0987

VL - 57

SP - 99

EP - 151

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

IS - 1

ER -

Rostami-Hochaghan A, Sjögren E, Abrahamsson B, Augustijns P, Becker D, Bolger MB et al. In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences. 2014 Jun 16;57(1):99-151. doi: 10.1016/j.ejps.2014.02.010